InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: KCNIP3

Summary

InnateDB Gene

IDBG-61167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNIP3

Gene Name

Kv channel interacting protein 3, calsenilin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000115041

Encoded Proteins

IDBP-61169

Kv channel interacting protein 3, calsenilin

IDBP-61171

Kv channel interacting protein 3, calsenilin

IDBP-479656

Kv channel interacting protein 3, calsenilin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:95297304-95386083

Strand

Forward strand

Band

q11.1

Transcripts

ENST00000295225	ENSP00000295225
ENST00000360990	ENSP00000354261
ENST00000377181
ENST00000486055
ENST00000475491
ENST00000461336
ENST00000468529	ENSP00000417499

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005244	voltage-gated ion channel activity
GO:0005267	potassium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0015459	potassium channel regulator activity
GO:0043565	sequence-specific DNA binding
GO:0044325	ion channel binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006886	intracellular protein transport
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0019233	sensory perception of pain
GO:0034765	regulation of ion transmembrane transport
GO:0043523	regulation of neuron apoptotic process
GO:0048265	response to pain
GO:0048266	behavioral response to pain
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0032993	protein-DNA complex
GO:0043679	axon terminus

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000079056

View Gene Order

Pathways

NETPATH

NetPath_15

IL3 pathway

NetPath_23

TSH pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.437376

RefSeq

NM_001034914 NM_013434

HUGO

OMIM

CCDS

CCDS2013 CCDS33245

HPRD

05232

IMGT

EMBL

GenPept

RNA Seq Atlas