Version 5.4
Homo sapiens Gene: CPLX1
Summary
InnateDB Gene IDBG-6120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPLX1
Gene Name complexin 1
Synonyms CPX-I; CPX1
Species Homo sapiens
Ensembl Gene ENSG00000168993
Encoded Proteins
IDBP-6122
complexin 1
IDBP-484595
complexin 1
IDBP-482910
complexin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:784957-826198
Strand Reverse strand
Band p16.3
Transcripts
ENST00000304062 ENSP00000305613
ENST00000505203 ENSP00000425960
ENST00000506404
ENST00000504062 ENSP00000421947
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005326 neurotransmitter transporter activity
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0014047 glutamate secretion
GO:0016079 synaptic vesicle exocytosis
GO:0030073 insulin secretion
Cellular Component
GO:0005829 cytosol
GO:0030425 dendrite
GO:0031201 SNARE complex
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0045202 synapse
GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_15293
Dopamine Neurotransmitter Release Cycle pathway
REACT_15309
Acetylcholine Neurotransmitter Release Cycle pathway
REACT_15425
Serotonin Neurotransmitter Release Cycle pathway
REACT_12591
Glutamate Neurotransmitter Release Cycle pathway
REACT_23947
GABA synthesis, release, reuptake and degradation pathway
REACT_15418
Norepinephrine Neurotransmitter Release Cycle pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.478930 Hs.593120
RefSeq NM_006651
HUGO
OMIM
CCDS CCDS46995
HPRD 09233
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca