Version 5.4
Homo sapiens Gene: GAK
Summary
InnateDB Gene IDBG-6126.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAK
Gene Name cyclin G associated kinase
Synonyms DNAJ26; DNAJC26
Species Homo sapiens
Ensembl Gene ENSG00000178950
Encoded Proteins
IDBP-6128
cyclin G associated kinase
IDBP-480166
cyclin G associated kinase
IDBP-481299
cyclin G associated kinase
IDBP-479516
cyclin G associated kinase
IDBP-473775
cyclin G associated kinase
IDBP-481790
cyclin G associated kinase
IDBP-479949
cyclin G associated kinase
IDBP-478026
cyclin G associated kinase
IDBP-485055
cyclin G associated kinase
IDBP-480823
cyclin G associated kinase
IDBP-813720
cyclin G associated kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. [provided by RefSeq, Jul 2008]
In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the \'cyclin box.\' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:849276-932373
Strand Reverse strand
Band p16.3
Transcripts
ENST00000314167 ENSP00000314499
ENST00000502799
ENST00000504668 ENSP00000424553
ENST00000511163 ENSP00000421361
ENST00000509566
ENST00000515868
ENST00000511345
ENST00000511980 ENSP00000421049
ENST00000510799 ENSP00000426062
ENST00000504947
ENST00000504435
ENST00000505819 ENSP00000426908
ENST00000507580 ENSP00000426728
ENST00000502656 ENSP00000424701
ENST00000507991
ENST00000512325 ENSP00000421814
ENST00000510022
ENST00000511229 ENSP00000422391
ENST00000511983
ENST00000507124
ENST00000513935
ENST00000618573 ENSP00000484475
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 24 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0020037 heme binding
Biological Process
GO:0006118 electron transport
GO:0006468 protein phosphorylation
GO:0007029 endoplasmic reticulum organization
GO:0007030 Golgi organization
GO:0007049 cell cycle
GO:0008152 metabolic process
GO:0009913 epidermal cell differentiation
GO:0016310 phosphorylation
GO:0035622 intrahepatic bile duct development
GO:0048468 cell development
GO:0048853 forebrain morphogenesis
GO:0061436 establishment of skin barrier
GO:0072318 clathrin coat disassembly
GO:0072583 clathrin-mediated endocytosis
GO:2000179 positive regulation of neural precursor cell proliferation
Cellular Component
GO:0005794 Golgi apparatus
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062234
View Gene Order
ENSBTAG00000019188
Not yet available
Pathways
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.369607
RefSeq NM_001286833 NM_005255 XM_005272272 XM_005272273 XM_006713874
HUGO
OMIM
CCDS CCDS3340
HPRD 03631
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca