Version 5.4
Homo sapiens Gene: MED12L
Summary
InnateDB Gene IDBG-61393.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MED12L
Gene Name mediator complex subunit 12-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144893
Encoded Proteins
IDBP-61395
mediator complex subunit 12-like
IDBP-61397
mediator complex subunit 12-like
IDBP-384893
mediator complex subunit 12-like
IDBP-473509
mediator complex subunit 12-like
IDBP-482129
mediator complex subunit 12-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:151085697-151437072
Strand Forward strand
Band q25.1
Transcripts
ENST00000309237 ENSP00000310760
ENST00000273432 ENSP00000273432
ENST00000422248 ENSP00000403308
ENST00000469768
ENST00000474524 ENSP00000417235
ENST00000480026 ENSP00000417420
ENST00000491549
ENST00000468305
ENST00000488092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0016592 mediator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056476
View Gene Order
ENSBTAG00000021703
Not yet available
Cross-References
SwissProt Q86YW9
TrEMBL
UniProt Splice Variant
Entrez Gene 116931
UniGene Hs.58561 Hs.665544 Hs.666253
RefSeq NM_053002
HUGO HGNC:16050
OMIM 611318
CCDS CCDS33876
HPRD 10278
IMGT
EMBL AB046855 AF090917 AF388364 AF388365 AF399708 AK022714 CH471052
GenPept AAF24035 AAL09579 AAL09580 AAO38813 BAB13461 BAB14198 EAW78800
RNA Seq Atlas 116931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca