Homo sapiens Gene: GCM2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-61420.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | GCM2 | ||||||||||||||||||
Gene Name | glial cells missing homolog 2 (Drosophila) | ||||||||||||||||||
Synonyms | GCMB; hGCMb | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000124827 | ||||||||||||||||||
Encoded Proteins |
glial cells missing homolog 2 (Drosophila)
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene is a homolog of the Drosophila glial cells missing gene, which is thought to act as a binary switch between neuronal and glial cell determination. The protein encoded by this gene contains a conserved N-terminal GCM motif that has DNA-binding activity. The protein is a transcription factor that acts as a master regulator of parathyroid development. It has been suggested that this transcription factor might mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. Mutations in this gene are associated with hypoparathyroidism. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 6:10873223-10881941 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p24.2 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||
SwissProt | O75603 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 9247 | ||||||||||||||||||
UniGene | Hs.227098 | ||||||||||||||||||
RefSeq | NM_004752 | ||||||||||||||||||
HUGO | HGNC:4198 | ||||||||||||||||||
OMIM | 603716 | ||||||||||||||||||
CCDS | CCDS4517 | ||||||||||||||||||
HPRD | |||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF079550 AF091149 AL024498 AL357497 BC069603 BC117316 BC117318 CH471087 FJ655849 | ||||||||||||||||||
GenPept | AAC33792 AAC98097 AAH69603 AAI17317 AAI17319 ACV69998 CAI16225 CAI20518 EAW55287 | ||||||||||||||||||
RNA Seq Atlas | 9247 | ||||||||||||||||||