Version 5.4
Homo sapiens Gene: RAD51C
Summary
InnateDB Gene IDBG-61454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAD51C
Gene Name RAD51 homolog C (S. cerevisiae)
Synonyms BROVCA3; FANCO; R51H3; RAD51L2
Species Homo sapiens
Ensembl Gene ENSG00000108384
Encoded Proteins
IDBP-61456
RAD51 homolog C (S. cerevisiae)
IDBP-382374
RAD51 homolog C (S. cerevisiae)
IDBP-382377
RAD51 homolog C (S. cerevisiae)
IDBP-382380
RAD51 homolog C (S. cerevisiae)
IDBP-760614
IDBP-584707
RAD51 homolog C (S. cerevisiae)
IDBP-596608
RAD51 homolog C (S. cerevisiae)
IDBP-603954
RAD51 homolog C (S. cerevisiae)
IDBP-592430
RAD51 homolog C (S. cerevisiae)
IDBP-763029
IDBP-761219
IDBP-758539
IDBP-809006
RAD51 paralog C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:58692573-58735611
Strand Forward strand
Band q22
Transcripts
ENST00000337432 ENSP00000336701
ENST00000421782 ENSP00000391450
ENST00000425173 ENSP00000407282
ENST00000413590 ENSP00000401741
ENST00000461271 ENSP00000464056
ENST00000487921
ENST00000475762 ENSP00000432421
ENST00000476741
ENST00000486827 ENSP00000436761
ENST00000487525 ENSP00000431637
ENST00000482007 ENSP00000433332
ENST00000461706
ENST00000583539 ENSP00000463121
ENST00000584804 ENSP00000463658
ENST00000578151
ENST00000584617 ENSP00000463473
ENST00000581221
ENST00000622327 ENSP00000482326
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000400 four-way junction DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0008821 crossover junction endodeoxyribonuclease activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006200 ATP catabolic process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0007062 sister chromatid cohesion
GO:0007066 female meiosis sister chromatid cohesion
GO:0007131 reciprocal meiotic recombination
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0007596 blood coagulation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex
GO:0033065 Rad51C-XRCC3 complex
GO:0048471 perinuclear region of cytoplasm
GO:0048476 Holliday junction resolvase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007646
View Gene Order
ENSBTAG00000015036
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_27271
Meiotic recombination pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
REACT_604
Hemostasis pathway
KEGG
hsa03440
Homologous recombination pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5889
UniGene Hs.412587
RefSeq NM_002876 NM_058216 XM_006722001 XM_006722004 XM_006722005 XM_006722006
HUGO HGNC:9820
OMIM 602774
CCDS CCDS11611 CCDS45745
HPRD 04143
IMGT
EMBL
GenPept
RNA Seq Atlas 5889

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca