Version 5.4
Homo sapiens Gene: HNRNPH1
Summary
InnateDB Gene IDBG-61485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPH1
Gene Name heterogeneous nuclear ribonucleoprotein H1 (H)
Synonyms hnRNPH; HNRPH; HNRPH1
Species Homo sapiens
Ensembl Gene ENSG00000169045
Encoded Proteins
IDBP-61487
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-61489
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-243624
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-382539
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-479334
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-483650
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-480636
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-478139
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-481390
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-474927
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-484334
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-473682
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-478020
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-483307
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-483568
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-476376
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-474284
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-477622
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-480077
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-481733
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-485065
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-481851
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-482186
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-477915
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-477556
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-478284
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-477784
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-481326
heterogeneous nuclear ribonucleoprotein H1 (H)
IDBP-481624
heterogeneous nuclear ribonucleoprotein H1 (H)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:179614178-179634784
Strand Reverse strand
Band q35.3
Transcripts
ENST00000356731 ENSP00000349168
ENST00000329433 ENSP00000327539
ENST00000393432 ENSP00000377082
ENST00000442819 ENSP00000397797
ENST00000502904
ENST00000515481
ENST00000514332
ENST00000510678 ENSP00000425851
ENST00000510411 ENSP00000426275
ENST00000523449 ENSP00000429673
ENST00000524179
ENST00000519033 ENSP00000429481
ENST00000521720
ENST00000502632
ENST00000519958 ENSP00000427845
ENST00000523136 ENSP00000430445
ENST00000504549
ENST00000514731
ENST00000521173 ENSP00000428620
ENST00000523921 ENSP00000429270
ENST00000503105 ENSP00000427408
ENST00000504779 ENSP00000422955
ENST00000520415
ENST00000518548
ENST00000508103 ENSP00000425732
ENST00000506721 ENSP00000420850
ENST00000523137 ENSP00000427986
ENST00000505811 ENSP00000424087
ENST00000510431 ENSP00000423140
ENST00000519056 ENSP00000430970
ENST00000522958
ENST00000521790 ENSP00000430156
ENST00000504348 ENSP00000427388
ENST00000513225 ENSP00000426518
ENST00000524180
ENST00000513972
ENST00000519943
ENST00000519707
ENST00000519455
ENST00000515158 ENSP00000421695
ENST00000521116 ENSP00000429661
ENST00000505087
ENST00000515714 ENSP00000425343
ENST00000512273 ENSP00000427351
ENST00000503664 ENSP00000426726
ENST00000515446
ENST00000513230
ENST00000522256 ENSP00000429179
ENST00000518602
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 161 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 161 [view]
Protein-Protein 161 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008266 poly(U) RNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007850
View Gene Order
ENSBTAG00000009389
Not yet available
Pathways
NETPATH
REACTOME
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.604001 Hs.624216 Hs.695152
RefSeq NM_001257293 NM_005520 XM_005265895 XM_005265896 XM_006714863
HUGO
OMIM
CCDS CCDS4446
HPRD 03021
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca