InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CANX

Summary

InnateDB Gene

IDBG-61587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CANX

Gene Name

calnexin

Synonyms

CNX; IP90; P90

Species

Homo sapiens

Ensembl Gene

ENSG00000127022

Encoded Proteins

IDBP-61589

calnexin

IDBP-382576

calnexin

IDBP-473641

calnexin

IDBP-478767

calnexin

IDBP-481088

calnexin

IDBP-481950

calnexin

IDBP-473503

calnexin

IDBP-485335

calnexin

IDBP-474713

calnexin

IDBP-484636

calnexin

IDBP-476498

calnexin

IDBP-482472

calnexin

IDBP-485334

calnexin

IDBP-473907

calnexin

IDBP-479816

calnexin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:179678628-179730925

Strand

Forward strand

Band

q35.3

Transcripts

ENST00000247461	ENSP00000247461
ENST00000452673	ENSP00000391646
ENST00000514383	ENSP00000424341
ENST00000502296	ENSP00000424745
ENST00000504734	ENSP00000424063
ENST00000502498	ENSP00000425246
ENST00000507307	ENSP00000426052
ENST00000504579	ENSP00000426425
ENST00000513246	ENSP00000421813
ENST00000502673	ENSP00000421107
ENST00000506654	ENSP00000426555
ENST00000514032	ENSP00000427115
ENST00000510810	ENSP00000424740
ENST00000509563	ENSP00000421434
ENST00000503126
ENST00000508787	ENSP00000424140
ENST00000506298
ENST00000505090
ENST00000503303

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	125 [view]
Protein-Protein	124 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0034185	apolipoprotein binding
GO:0035255	ionotropic glutamate receptor binding
GO:0044822	poly(A) RNA binding
GO:0051082	unfolded protein binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006457	protein folding
GO:0007568	aging
GO:0009306	protein secretion
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0048488	synaptic vesicle endocytosis
GO:0061077	chaperone-mediated protein folding
GO:0072583	clathrin-mediated endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005840	ribosome
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0032839	dendrite cytoplasm
GO:0042470	melanosome
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane