InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SNRNP200

Summary

InnateDB Gene

IDBG-61602.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNRNP200

Gene Name

small nuclear ribonucleoprotein 200kDa (U5)

Synonyms

ASCC3L1; BRR2; HELIC2; RP33; U5-200KD

Species

Homo sapiens

Ensembl Gene

ENSG00000144028

Encoded Proteins

IDBP-61604

small nuclear ribonucleoprotein 200kDa (U5)

IDBP-382874

small nuclear ribonucleoprotein 200kDa (U5)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Pre-mRNA splicing is catalyzed by the spliceosome, a complex of specialized RNA and protein subunits that removes introns from a transcribed pre-mRNA segment. The spliceosome consists of small nuclear RNA proteins (snRNPs) U1, U2, U4, U5 and U6, together with approximately 80 conserved proteins. U5 snRNP contains nine specific proteins. This gene encodes one of the U5 snRNP-specific proteins. This protein belongs to the DEXH-box family of putative RNA helicases. It is a core component of U4/U6-U5 snRNPs and appears to catalyze an ATP-dependent unwinding of U4/U6 RNA duplices. Mutations in this gene cause autosomal-dominant retinitis pigmentosa. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:96274336-96305515

Strand

Reverse strand

Band

q11.2

Transcripts

ENST00000323853	ENSP00000317123
ENST00000429650	ENSP00000387870
ENST00000497539
ENST00000480835
ENST00000484372
ENST00000493271
ENST00000480242
ENST00000480615

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 157 experimentally validated interaction(s) in this database.

Experimentally validated
Total	157 [view]
Protein-Protein	156 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004004	ATP-dependent RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0016787	hydrolase activity
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000354	cis assembly of pre-catalytic spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0001649	osteoblast differentiation
GO:0006200	ATP catabolic process
GO:0008152	metabolic process
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005682	U5 snRNP
GO:0016020	membrane
GO:0019013	viral nucleocapsid
GO:0030529	ribonucleoprotein complex
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003660

View Gene Order

ENSBTAG00000000848

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_1753

mRNA Splicing - Minor Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.246112 Hs.609834 Hs.612595

RefSeq

NM_014014

HUGO

OMIM

CCDS

CCDS2020

HPRD

03391

IMGT

EMBL

GenPept

RNA Seq Atlas