Version 5.4
Homo sapiens Gene: SMG8
Summary
InnateDB Gene IDBG-61620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMG8
Gene Name smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167447
Encoded Proteins
IDBP-61622
smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
IDBP-599997
smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
IDBP-759396
IDBP-763211
IDBP-764496
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:59209400-59215247
Strand Forward strand
Band q22
Transcripts
ENST00000300917 ENSP00000300917
ENST00000543872 ENSP00000438748
ENST00000580798 ENSP00000463175
ENST00000582469 ENSP00000462931
ENST00000580498
ENST00000578922 ENSP00000462119
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0045859 regulation of protein kinase activity
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020495
View Gene Order
ENSBTAG00000003365
Not yet available
Pathways
NETPATH
REACTOME
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL J3KTD7
UniProt Splice Variant
Entrez Gene 55181
UniGene Hs.624528 Hs.7296
RefSeq NM_018149
HUGO HGNC:25551
OMIM 613175
CCDS CCDS11615
HPRD 08551
IMGT
EMBL AC099850
GenPept
RNA Seq Atlas 55181

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca