InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CLTC

Summary

InnateDB Gene

IDBG-61767.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLTC

Gene Name

clathrin, heavy chain (Hc)

Synonyms

CHC; CHC17; CLH-17; CLTCL2; Hc

Species

Homo sapiens

Ensembl Gene

ENSG00000141367

Encoded Proteins

IDBP-61769

clathrin, heavy chain (Hc)

IDBP-244413

clathrin, heavy chain (Hc)

IDBP-760079

IDBP-759183

IDBP-758434

IDBP-761672

IDBP-762061

IDBP-763083

IDBP-811040

clathrin, heavy chain (Hc)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21364927

CLTC functions as a built-in molecular brake that ensures a tight control of basal NFKB activation and gene expression in un-stimulated cells. Defects in CLTC expression could potentially lead to chronic inflammation disorder.

InnateDB Annotation from Orthologs

Summary

PMID 21364927

[Mus musculus] Cltc functions as a built-in molecular brake that ensures a tight control of basal NFKB activation and gene expression in un-stimulated cells. Defects in Cltc expression could potentially lead to chronic inflammation disorder.

Entrez Gene

Summary

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:59619689-59696956

Strand

Forward strand

Band

q23.1

Transcripts

ENST00000269122	ENSP00000269122
ENST00000393043	ENSP00000376763
ENST00000472129
ENST00000483176	ENSP00000463068
ENST00000466513
ENST00000496076
ENST00000472651	ENSP00000465200
ENST00000475458	ENSP00000461977
ENST00000498711
ENST00000585198
ENST00000579456	ENSP00000462252
ENST00000580081	ENSP00000462592
ENST00000579815
ENST00000584313	ENSP00000463336
ENST00000621829	ENSP00000479606

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 167 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	167 [view]
Protein-Protein	167 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003725	double-stranded RNA binding
GO:0005198	structural molecule activity
GO:0005488	binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0032051	clathrin light chain binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0006886	intracellular protein transport
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006898	receptor-mediated endocytosis
GO:0007067	mitotic nuclear division
GO:0016192	vesicle-mediated transport
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031623	receptor internalization
GO:0033572	transferrin transport
GO:0045087	innate immune response (InnateDB)
GO:0061024	membrane organization
GO:1900126	negative regulation of hyaluronan biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005819	spindle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030117	membrane coat
GO:0030118	clathrin coat
GO:0030130	clathrin coat of trans-Golgi network vesicle
GO:0030132	clathrin coat of coated pit
GO:0030136	clathrin-coated vesicle
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0042470	melanosome
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0071439	clathrin complex