Version 5.4
| Homo sapiens Gene: IL31 | |||||
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| Summary | |||||
| InnateDB Gene | IDBG-62191.6 | ||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
| Gene Symbol | IL31 | ||||
| Gene Name | interleukin 31 | ||||
| Synonyms | |||||
| Species | Homo sapiens | ||||
| Ensembl Gene | ENSG00000204671 | ||||
| Encoded Proteins |
interleukin 31
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| Protein Structure | |||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||
| InnateDB Annotation | |||||
| Summary |
IL31 is a pruritogenic cytokine in human mast cells and its secretion is induced by antimicrobial peptides human beta-defensins and cathelicidin LL-37.
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| Entrez Gene | |||||
| Summary |
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008] |
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| Gene Information | |||||
| Type | Protein coding | ||||
| Genomic Location | Chromosome 12:122172030-122174199 | ||||
| Strand | Reverse strand | ||||
| Band | q24.31 | ||||
| Transcripts |
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| Interactions | |||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||
| No orthologs found for this gene | |||||
| Cross-References | |||||
| SwissProt | |||||
| TrEMBL | |||||
| UniProt Splice Variant | |||||
| Entrez Gene | |||||
| UniGene | Hs.569071 | ||||
| RefSeq | NM_001014336 | ||||
| HUGO | |||||
| OMIM | |||||
| CCDS | CCDS31919 | ||||
| HPRD | 11877 | ||||
| IMGT | |||||
| EMBL | |||||
| GenPept | |||||
| RNA Seq Atlas | |||||