InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UNC13B

Summary

InnateDB Gene

IDBG-62347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UNC13B

Gene Name

unc-13 homolog B (C. elegans)

Synonyms

MUNC13; UNC13; Unc13h2

Species

Homo sapiens

Ensembl Gene

ENSG00000198722

Encoded Proteins

IDBP-62349

unc-13 homolog B (C. elegans)

IDBP-62351

unc-13 homolog B (C. elegans)

IDBP-236722

unc-13 homolog B (C. elegans)

IDBP-807845

unc-13 homolog B (C. elegans)

IDBP-807850

unc-13 homolog B (C. elegans)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:35161992-35405338

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000378496	ENSP00000367757
ENST00000378495	ENSP00000367756
ENST00000396787	ENSP00000380006
ENST00000485086
ENST00000481299
ENST00000619578	ENSP00000479261
ENST00000617908	ENSP00000484432

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0019992	diacylglycerol binding
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007528	neuromuscular junction development
GO:0007588	excretion
GO:0016081	synaptic vesicle docking involved in exocytosis
GO:0016082	synaptic vesicle priming
GO:0035249	synaptic transmission, glutamatergic
GO:0035556	intracellular signal transduction
GO:0048172	regulation of short-term neuronal synaptic plasticity
GO:0060384	innervation