Version 5.4
Homo sapiens Gene: SLC33A1
Summary
InnateDB Gene IDBG-62363.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC33A1
Gene Name solute carrier family 33 (acetyl-CoA transporter), member 1
Synonyms ACATN; AT-1; AT1; CCHLND; SPG42
Species Homo sapiens
Ensembl Gene ENSG00000169359
Encoded Proteins
IDBP-62365
solute carrier family 33 (acetyl-CoA transporter), member 1
IDBP-244830
solute carrier family 33 (acetyl-CoA transporter), member 1
IDBP-473608
solute carrier family 33 (acetyl-CoA transporter), member 1
IDBP-484942
solute carrier family 33 (acetyl-CoA transporter), member 1
IDBP-480048
solute carrier family 33 (acetyl-CoA transporter), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:155821024-155854429
Strand Reverse strand
Band q25.31
Transcripts
ENST00000359479 ENSP00000352456
ENST00000392845 ENSP00000376587
ENST00000475842 ENSP00000419066
ENST00000496772 ENSP00000419165
ENST00000468581 ENSP00000418847
ENST00000460729
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008521 acetyl-CoA transporter activity
Biological Process
GO:0006810 transport
GO:0008219 cell death
GO:0015876 acetyl-CoA transport
GO:0055085 transmembrane transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027822
View Gene Order
ENSBTAG00000014318
Not yet available
Pathways
NETPATH
REACTOME
REACT_22285
Transport of vitamins, nucleosides, and related molecules pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa00604
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.478031 Hs.596803 Hs.611929 Hs.623064
RefSeq NM_001190992 NM_004733 XM_006713822
HUGO
OMIM
CCDS CCDS3173
HPRD 04734
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca