Version 5.4
Homo sapiens Gene: TRPM4
Summary
InnateDB Gene IDBG-62419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPM4
Gene Name transient receptor potential cation channel, subfamily M, member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130529
Encoded Proteins
IDBP-62421
transient receptor potential cation channel, subfamily M, member 4
IDBP-383157
transient receptor potential cation channel, subfamily M, member 4
IDBP-761490
IDBP-761720
IDBP-761516
IDBP-765884
IDBP-765908
IDBP-813810
transient receptor potential cation channel, subfamily M, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49157741-49211836
Strand Forward strand
Band q13.33
Transcripts
ENST00000252826 ENSP00000252826
ENST00000427978 ENSP00000407492
ENST00000598697 ENSP00000468989
ENST00000596338
ENST00000595071
ENST00000597316 ENSP00000471236
ENST00000598691 ENSP00000473231
ENST00000595882
ENST00000595519 ENSP00000469893
ENST00000598502 ENSP00000470229
ENST00000601347
ENST00000599459
ENST00000594568
ENST00000599628 ENSP00000483753
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005227 calcium activated cation channel activity
GO:0005262 calcium channel activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
Biological Process
GO:0002407 dendritic cell chemotaxis
GO:0002724 regulation of T cell cytokine production
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0008284 positive regulation of cell proliferation
GO:0016925 protein sumoylation
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038260
View Gene Order
ENSBTAG00000006139
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_169333
TRP channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.467101
RefSeq NM_001195227 NM_017636 XM_005259018 XM_006723249
HUGO
OMIM
CCDS CCDS33073 CCDS56098
HPRD 09502
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca