InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ZAP70

Summary

InnateDB Gene

IDBG-62509.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZAP70

Gene Name

zeta-chain (TCR) associated protein kinase 70kDa

Synonyms

SRK; STCD; STD; TZK; ZAP-70

Species

Homo sapiens

Ensembl Gene

ENSG00000115085

Encoded Proteins

IDBP-62511

zeta-chain (TCR) associated protein kinase 70kDa

IDBP-383238

zeta-chain (TCR) associated protein kinase 70kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:97713560-97739862

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000264972	ENSP00000264972
ENST00000451498	ENSP00000400475
ENST00000483781
ENST00000463643
ENST00000498836
ENST00000487283
ENST00000495754
ENST00000489250

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	85 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0002250	adaptive immune response
GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030217	T cell differentiation
GO:0035556	intracellular signal transduction
GO:0042110	T cell activation
GO:0042113	B cell activation
GO:0043366	beta selection
GO:0045059	positive thymic T cell selection
GO:0045060	negative thymic T cell selection
GO:0045061	thymic T cell selection
GO:0045582	positive regulation of T cell differentiation
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0046641	positive regulation of alpha-beta T cell proliferation
GO:0046777	protein autophosphorylation
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050852	T cell receptor signaling pathway
GO:0070489	T cell aggregation
GO:0072678	T cell migration

Cellular Component

GO:0001772	immunological synapse
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0042101	T cell receptor complex
GO:0045121	membrane raft