Version 5.4
Homo sapiens Gene: KNTC1
Summary
InnateDB Gene IDBG-62630.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KNTC1
Gene Name kinetochore associated 1
Synonyms ROD
Species Homo sapiens
Ensembl Gene ENSG00000184445
Encoded Proteins
IDBP-62632
kinetochore associated 1
IDBP-384660
kinetochore associated 1
IDBP-384666
kinetochore associated 1
IDBP-390043
kinetochore associated 1
IDBP-586225
kinetochore associated 1
IDBP-594335
kinetochore associated 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:122527246-122626396
Strand Forward strand
Band q24.31
Transcripts
ENST00000333479 ENSP00000328236
ENST00000377192
ENST00000450485 ENSP00000397992
ENST00000436959 ENSP00000408760
ENST00000423927 ENSP00000397140
ENST00000535410
ENST00000535186
ENST00000545065
ENST00000541466
ENST00000546125 ENSP00000439119
ENST00000536625
ENST00000542727
ENST00000539013
ENST00000541427
ENST00000534995 ENSP00000437344
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006355 regulation of transcription, DNA-templated
GO:0006461 protein complex assembly
GO:0007067 mitotic nuclear division
GO:0007093 mitotic cell cycle checkpoint
GO:0007096 regulation of exit from mitosis
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005828 kinetochore microtubule
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029414
View Gene Order
ENSBTAG00000019278
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.300559 Hs.627642 Hs.689083
RefSeq NM_014708 XM_006719706
HUGO
OMIM
CCDS CCDS45002
HPRD 09561
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca