Version 5.4
Homo sapiens Gene: CD83
Summary
InnateDB Gene IDBG-62750.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD83
Gene Name CD83 molecule
Synonyms BL11; HB15
Species Homo sapiens
Ensembl Gene ENSG00000112149
Encoded Proteins
IDBP-62752
CD83 molecule
IDBP-809523
CD83 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:14117256-14136918
Strand Forward strand
Band p23
Transcripts
ENST00000379153 ENSP00000368450
ENST00000612003 ENSP00000480760
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 3 [view]
Protein-DNA 6 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0014070 response to organic cyclic compound
GO:0032713 negative regulation of interleukin-4 production
GO:0032733 positive regulation of interleukin-10 production
GO:0032743 positive regulation of interleukin-2 production
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015396
View Gene Order
ENSBTAG00000031430
Not yet available
Cross-References
SwissProt Q01151
TrEMBL
UniProt Splice Variant
Entrez Gene 9308
UniGene Hs.595133 Hs.623682 Hs.715968
RefSeq NM_001040280 NM_004233 NM_001251901
HUGO HGNC:1703
OMIM 604534
CCDS CCDS4532 CCDS75403
HPRD 05170
IMGT
EMBL AL022396 AL133259 BC030830 CR457019 S53354 Z11697
GenPept AAB25085 AAH30830 CAA77755 CAB96723 CAG33300 CAI20374
RNA Seq Atlas 9308

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca