Bos taurus Gene: TAP1 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-628856.2 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | TAP1 | ||||||||||||||||||||||||||
Gene Name | antigen peptide transporter 1 | ||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000008953 | ||||||||||||||||||||||||||
Encoded Proteins |
antigen peptide transporter 1
antigen peptide transporter 1
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Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168394:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014] |
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Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 23:7117863-7126822 | ||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||
REACTOME |
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
ER-Phagosome pathway pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
ER-Phagosome pathway pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
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KEGG |
Antigen processing and presentation pathway
ABC transporters pathway
Primary immunodeficiency pathway
Phagosome pathway
Antigen processing and presentation pathway
ABC transporters pathway
Primary immunodeficiency pathway
Phagosome pathway
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INOH | |||||||||||||||||||||||||||
PID NCI |
Direct p53 effectors
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Cross-References | |||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||
TrEMBL | A6QPZ6 F1MVY8 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 524959 | ||||||||||||||||||||||||||
UniGene | Bt.58251 | ||||||||||||||||||||||||||
RefSeq | NM_001098058 XM_005223252 | ||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | BC149569 DAAA02054878 | ||||||||||||||||||||||||||
GenPept | AAI49570 | ||||||||||||||||||||||||||
RNA Seq Atlas | 524959 | ||||||||||||||||||||||||||