InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PEX1

Summary

InnateDB Gene

IDBG-629020.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEX1

Gene Name

peroxisome biogenesis factor 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000024431

Encoded Proteins

IDBP-680420

peroxisomal biogenesis factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127980:
This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. [provided by RefSeq, Jul 2008]
This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:9637833-9723444

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000033872

ENSBTAP00000033778

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0009378	four-way junction helicase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0032403	protein complex binding
GO:0042623	ATPase activity, coupled

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006625	protein targeting to peroxisome
GO:0007031	peroxisome organization
GO:0008152	metabolic process
GO:0016558	protein import into peroxisome matrix
GO:0060152	microtubule-based peroxisome localization

Cellular Component

GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000127980

View Gene Order

ENSMUSG00000005907

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04146

Peroxisome pathway

mmu04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.20771

RefSeq

NM_001192071

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas