Bos taurus Gene: PLCG2 | |||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-629513.3 | ||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||
Gene Symbol | PLCG2 | ||||||||||||||||||||||||||||||||
Gene Name | Uncharacterized protein | ||||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000002103 | ||||||||||||||||||||||||||||||||
Encoded Proteins |
phospholipase C, gamma 2 (phosphatidylinositol-specific)
|
||||||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||
Summary |
[Homo sapiens] PLCG2, 1,4,5-triphosphate and intracellular calcium are required for the LPS-induced innate immune response pathway, where release of intracellular calcium mediates TLR4 trafficking and subsequent activation of IRF3. (Demonstrated in mouse)
[Mus musculus] Plcg2, 1,4,5-triphosphate and intracellular calcium are required for the LPS-induced innate immune response pathway, where release of intracellular calcium mediates Tlr4 trafficking and subsequent activation of Irf3.
|
||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197943:
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. [provided by RefSeq, Sep 2011] The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014] |
||||||||||||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 18:8427455-8516798 | ||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||
NETPATH |
EGFR1 pathway
KitReceptor pathway
TCR pathway
BCR pathway
IL4 pathway
RANKL pathway
Leptin pathway
|
||||||||||||||||||||||||||||||||
REACTOME |
DAP12 signaling pathway
DAP12 interactions pathway
Role of phospholipids in phagocytosis pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
GPVI-mediated activation cascade pathway
Synthesis of IP3 and IP4 in the cytosol pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
Adaptive Immune System pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Inositol phosphate metabolism pathway
Metabolism pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
FCERI mediated MAPK activation pathway
Hemostasis pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Hemostasis pathway
Role of phospholipids in phagocytosis pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
GPVI-mediated activation cascade pathway
Fc epsilon receptor (FCERI) signaling pathway
FCERI mediated Ca+2 mobilization pathway
Toll-Like Receptors Cascades pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Adaptive Immune System pathway
Inositol phosphate metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
FCERI mediated MAPK activation pathway
DAP12 interactions pathway
DAP12 signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
|
||||||||||||||||||||||||||||||||
KEGG |
Vibrio cholerae infection pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Non-small cell lung cancer pathway
Inositol phosphate metabolism pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
ErbB signaling pathway pathway
Leukocyte transendothelial migration pathway
Glioma pathway
Phosphatidylinositol signaling system pathway
B cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Calcium signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Osteoclast differentiation pathway
ErbB signaling pathway pathway
VEGF signaling pathway pathway
Calcium signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Phosphatidylinositol signaling system pathway
Glioma pathway
Leukocyte transendothelial migration pathway
Inositol phosphate metabolism pathway
Non-small cell lung cancer pathway
B cell receptor signaling pathway pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
Osteoclast differentiation pathway
|
||||||||||||||||||||||||||||||||
INOH |
CD4 T cell receptor signaling pathway
B cell receptor signaling pathway
FGF signaling pathway pathway
VEGF signaling pathway pathway
HGF signaling pathway pathway
Inositol phosphate metabolism pathway
|
||||||||||||||||||||||||||||||||
PID NCI |
EPO signaling pathway
BCR signaling pathway
|
||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||
UniGene | Bt.109547 Bt.109862 Bt.63916 Bt.64782 | ||||||||||||||||||||||||||||||||
RefSeq | XM_003585201 XM_003587203 | ||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||