InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNB2L1

Summary

InnateDB Gene

IDBG-63034.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNB2L1

Gene Name

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

Synonyms

Gnb2-rs1; H12.3; HLC-7; PIG21; RACK1

Species

Homo sapiens

Ensembl Gene

ENSG00000204628

Encoded Proteins

IDBP-63036

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-483294

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-475070

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-475897

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-474153

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-483191

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-479605

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-477968

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-484161

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-480084

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-483546

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-482761

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-482146

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-474816

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-474542

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-484705

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-477744

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-475339

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-474624

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-473886

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-480540

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

IDBP-480184

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24323043

GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:181236909-181248096

Strand

Reverse strand

Band

q35.3

Transcripts

ENST00000376817	ENSP00000366013
ENST00000511473	ENSP00000420936
ENST00000504325	ENSP00000422198
ENST00000514455	ENSP00000426708
ENST00000507756	ENSP00000422316
ENST00000509148	ENSP00000424654
ENST00000502905	ENSP00000426960
ENST00000511566	ENSP00000426101
ENST00000512805	ENSP00000426909
ENST00000504128	ENSP00000427677
ENST00000508682	ENSP00000424760
ENST00000507273
ENST00000509535	ENSP00000421838
ENST00000504726	ENSP00000426046
ENST00000511900	ENSP00000422768
ENST00000513060
ENST00000512968	ENSP00000425008
ENST00000510199	ENSP00000423569
ENST00000502844	ENSP00000422029
ENST00000507000	ENSP00000421416
ENST00000514183
ENST00000502548
ENST00000502890
ENST00000503494	ENSP00000426111
ENST00000506312	ENSP00000426270
ENST00000503081	ENSP00000424237
ENST00000508044
ENST00000515417
ENST00000513027	ENSP00000421356
ENST00000505461
ENST00000507261
ENST00000508963
ENST00000503170
ENST00000514318

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 242 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	242 [view]
Protein-Protein	240 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005080	protein kinase C binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008200	ion channel inhibitor activity
GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019899	enzyme binding
GO:0019903	protein phosphatase binding
GO:0030292	protein tyrosine kinase inhibitor activity
GO:0030971	receptor tyrosine kinase binding
GO:0032947	protein complex scaffold
GO:0042169	SH2 domain binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0001934	positive regulation of protein phosphorylation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049	cell cycle
GO:0007369	gastrulation
GO:0010629	negative regulation of gene expression
GO:0016032	viral process
GO:0017148	negative regulation of translation
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030308	negative regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0030822	positive regulation of cAMP catabolic process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464	positive regulation of protein homooligomerization
GO:0032880	regulation of protein localization
GO:0043065	positive regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043547	positive regulation of GTPase activity
GO:0045087	innate immune response (InnateDB)
GO:0048511	rhythmic process
GO:0050765	negative regulation of phagocytosis
GO:0051302	regulation of cell division
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051726	regulation of cell cycle
GO:0051898	negative regulation of protein kinase B signaling
GO:0051901	positive regulation of mitochondrial depolarization
GO:0061099	negative regulation of protein tyrosine kinase activity
GO:0090003	regulation of establishment of protein localization to plasma membrane
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2000114	regulation of establishment of cell polarity
GO:2000543	positive regulation of gastrulation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0001891	phagocytic cup
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0030425	dendrite
GO:0030496	midbody
GO:0043025	neuronal cell body
GO:0043204	perikaryon
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome