Homo sapiens Gene: GNB2L1
Summary
InnateDB Gene IDBG-63034.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol GNB2L1
Gene Name guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Synonyms Gnb2-rs1; H12.3; HLC-7; PIG21; RACK1;
Species Homo sapiens
Ensembl Gene ENSG00000204628
Encoded Proteins
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Protein Structure
InnateDB Annotation
Summary
GNB2L1 (RACK1) negatively regulates NFκB activation by interacting with CHUK and IKBKB. The interaction interferes with the recruitment of the IKK complex to TRAF2 .
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:180663909-180675096
Strand Reverse strand
Band q35.3
Transcripts
ENST00000376817 ENSP00000366013
ENST00000456394 ENSP00000394470
ENST00000511473 ENSP00000420936
ENST00000504325 ENSP00000422198
ENST00000514455 ENSP00000426708
ENST00000507756 ENSP00000422316
ENST00000509148 ENSP00000424654
ENST00000502905 ENSP00000426960
ENST00000511566 ENSP00000426101
ENST00000512805 ENSP00000426909
ENST00000504128 ENSP00000427677
ENST00000508682 ENSP00000424760
ENST00000507273
ENST00000509535 ENSP00000421838
ENST00000504726 ENSP00000426046
ENST00000511900 ENSP00000422768
ENST00000513060
ENST00000512968 ENSP00000425008
ENST00000510199 ENSP00000423569
ENST00000502844 ENSP00000422029
ENST00000507000 ENSP00000421416
ENST00000514183
ENST00000502548
ENST00000502890
ENST00000503494 ENSP00000426111
ENST00000506312 ENSP00000426270
ENST00000503081 ENSP00000424237
ENST00000508044
ENST00000515417
ENST00000513027 ENSP00000421356
ENST00000505461
ENST00000507261
ENST00000508963
ENST00000503170
ENST00000514318
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 220 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 220 [view]
Protein-Protein 219 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008200 ion channel inhibitor activity
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0019903 protein phosphatase binding
GO:0030292 protein tyrosine kinase inhibitor activity
GO:0030971 receptor tyrosine kinase binding
GO:0042169 SH2 domain binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007049 cell cycle
GO:0007369 gastrulation
GO:0017148 negative regulation of translation
GO:0019048 virus-host interaction
GO:0030178 negative regulation of Wnt receptor signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464 positive regulation of protein homooligomerization
GO:0032880 regulation of protein localization
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045087 innate immune response (InnateDB)
GO:0048511 rhythmic process
GO:0050765 negative regulation of phagocytosis
GO:0051302 regulation of cell division
GO:0051726 regulation of cell cycle
GO:0051898 negative regulation of protein kinase B signaling cascade
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0090003 regulation of establishment of protein localization to plasma membrane
GO:2000114 regulation of establishment of cell polarity
GO:2000543 positive regulation of gastrulation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0001891 phagocytic cup
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0015935 small ribosomal subunit
GO:0030425 dendrite
GO:0030496 midbody
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
AndrogenReceptor pathway
TNFalpha pathway
IL3 pathway
IL5 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Syndecan-2-mediated signaling events
CXCR4-mediated signaling events
TNF receptor signaling pathway
IGF1 pathway
p73 transcription factor network
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Regulation of Androgen receptor activity
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt P63244
TrEMBL D6R909 D6R9L0 D6R9Z1 D6RAC2 D6RAU2 D6RBD0 D6RDI0 D6REE5 D6RF23 D6RFX4 D6RFZ9 D6RGK8 D6RHH4 D6RHJ5 E9KL35 E9PD14 J3KPE3
UniProt Splice Variant
Entrez Gene 619571
UniGene Hs.735852
RefSeq NM_006098
HUGO 4399
OMIM 176981
CCDS CCDS34324
HPRD 01503
IMGT
EMBL AC008443 AK095666 AK222488 AY159316 AY336089 BC000214 BC000366 BC010119 BC014256 BC014788 BC017287 BC019093 BC019362 BC021993 BC032006 CH471165 CR456978 CR541909 GU727632 M24194
GenPept AAA59626 AAH00214 AAH00366 AAH10119 AAH14256 AAH14788 AAH17287 AAH19093 AAH19362 AAH21993 AAH32006 AAO21313 AAR24619 ADU87634 BAD96208 BAG53102 CAG33259 CAG46707 EAW53692 EAW53702
ImmGen GNB2L1 (murine)
RNA Seq Atlas 10399 619570 619571