Version 5.4
Homo sapiens Gene: ABCB9
Summary
InnateDB Gene IDBG-63048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCB9
Gene Name ATP-binding cassette, sub-family B (MDR/TAP), member 9
Synonyms EST122234; TAPL
Species Homo sapiens
Ensembl Gene ENSG00000150967
Encoded Proteins
IDBP-63050
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-63052
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-717515
IDBP-245665
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-373700
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-384724
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-717541
IDBP-594741
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-599955
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-584967
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-603834
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-596567
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-602677
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-590801
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-589593
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-593313
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-591589
ATP-binding cassette, sub-family B (MDR/TAP), member 9
IDBP-592909
ATP-binding cassette, sub-family B (MDR/TAP), member 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:122920951-122981649
Strand Reverse strand
Band q24.31
Transcripts
ENST00000280560 ENSP00000280560
ENST00000346530 ENSP00000280559
ENST00000344275 ENSP00000456813
ENST00000392439 ENSP00000376234
ENST00000426173 ENSP00000415967
ENST00000442028 ENSP00000394898
ENST00000442833 ENSP00000456375
ENST00000540285 ENSP00000441734
ENST00000542678 ENSP00000440288
ENST00000546289 ENSP00000442281
ENST00000537276 ENSP00000439871
ENST00000542448 ENSP00000440244
ENST00000538895
ENST00000541983
ENST00000545373 ENSP00000444834
ENST00000540971 ENSP00000441086
ENST00000536976 ENSP00000443433
ENST00000546077 ENSP00000443224
ENST00000541424 ENSP00000440138
ENST00000543935 ENSP00000443382
ENST00000622723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015440 peptide-transporting ATPase activity
GO:0016887 ATPase activity
GO:0022891 substrate-specific transmembrane transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0042803 protein homodimerization activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029408
View Gene Order
ENSBTAG00000008464
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa02010
ABC transporters pathway
hsa04142
Lysosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9NP78
TrEMBL F5GX86 F5GXZ5 F5GYI2 F5H5I5
UniProt Splice Variant
Entrez Gene 23457
UniGene Hs.511951
RefSeq NM_001243014 NM_001243013 NM_019624 NM_019625 NM_203444 XM_005253558 XM_005253559 XM_006719314
HUGO HGNC:50
OMIM 605453
CCDS CCDS58287 CCDS58286 CCDS58288 CCDS9241
HPRD 09262
IMGT
EMBL AB040953 AB045381 AB112582 AB112583 AB177852 AC026362 AC027290 AF216494 AK304295 BC017348
GenPept AAF89993 AAH17348 BAA96044 BAA97989 BAC98409 BAC98410 BAD66830 BAG65152
RNA Seq Atlas 23457

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca