InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RAD1

Summary

InnateDB Gene

IDBG-630489.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD1

Gene Name

cell cycle checkpoint protein RAD1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019209

Encoded Proteins

IDBP-681947

RAD1 homolog (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113456:
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:39265413-39274082

Strand

Forward strand

Band

Transcripts

ENSBTAT00000025568

ENSBTAP00000025568

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008408	3'-5' exonuclease activity

Biological Process

GO:0000077	DNA damage checkpoint
GO:0006281	DNA repair
GO:0021762	substantia nigra development
GO:0071479	cellular response to ionizing radiation
GO:0090305	nucleic acid phosphodiester bond hydrolysis