Version 5.4
Homo sapiens Gene: CA9
Summary
InnateDB Gene IDBG-63082.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CA9
Gene Name carbonic anhydrase IX
Synonyms CAIX; MN
Species Homo sapiens
Ensembl Gene ENSG00000107159
Encoded Proteins
IDBP-63084
carbonic anhydrase IX
IDBP-810225
carbonic anhydrase IX
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jul 2008]
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:35673856-35681159
Strand Forward strand
Band p13.3
Transcripts
ENST00000378357 ENSP00000367608
ENST00000493245
ENST00000485665
ENST00000617161 ENSP00000482050
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0002009 morphogenesis of an epithelium
GO:0006730 one-carbon metabolic process
GO:0015701 bicarbonate transport
GO:0033574 response to testosterone
GO:0042493 response to drug
GO:0044281 small molecule metabolic process
GO:0046903 secretion
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005730 nucleolus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0031528 microvillus membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028463
View Gene Order
ENSBTAG00000011420
Not yet available
Pathways
NETPATH
REACTOME
REACT_121123
Reversible hydration of carbon dioxide pathway
REACT_121092
Regulation of gene expression by Hypoxia-inducible Factor pathway
REACT_120956
Cellular responses to stress pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_111217
Metabolism pathway
KEGG
hsa00910
Nitrogen metabolism pathway
INOH
PID NCI
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.63287 Hs.713291
RefSeq NM_001216
HUGO
OMIM
CCDS CCDS6585
HPRD 04417
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca