Version 5.4
Homo sapiens Gene: MLF1
Summary
InnateDB Gene IDBG-63091.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLF1
Gene Name myeloid leukemia factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178053
Encoded Proteins
IDBP-63093
myeloid leukemia factor 1
IDBP-63095
myeloid leukemia factor 1
IDBP-244875
myeloid leukemia factor 1
IDBP-480779
myeloid leukemia factor 1
IDBP-484546
myeloid leukemia factor 1
IDBP-485217
myeloid leukemia factor 1
IDBP-480765
myeloid leukemia factor 1
IDBP-480742
myeloid leukemia factor 1
IDBP-484519
myeloid leukemia factor 1
IDBP-476105
myeloid leukemia factor 1
IDBP-483536
myeloid leukemia factor 1
IDBP-476704
myeloid leukemia factor 1
IDBP-483601
myeloid leukemia factor 1
IDBP-474615
myeloid leukemia factor 1
IDBP-809221
myeloid leukemia factor 1
IDBP-809222
myeloid leukemia factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:158571163-158607252
Strand Forward strand
Band q25.32
Transcripts
ENST00000359117 ENSP00000352025
ENST00000355893 ENSP00000348157
ENST00000392822 ENSP00000376568
ENST00000491767 ENSP00000420410
ENST00000484955 ENSP00000417835
ENST00000498592 ENSP00000419636
ENST00000471745 ENSP00000420134
ENST00000497004
ENST00000495452 ENSP00000419775
ENST00000477042 ENSP00000419637
ENST00000469452 ENSP00000418595
ENST00000482628 ENSP00000417141
ENST00000478894 ENSP00000417777
ENST00000487838 ENSP00000419241
ENST00000466246 ENSP00000417278
ENST00000618075 ENSP00000484169
ENST00000619577 ENSP00000483337
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 65 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0002318 myeloid progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0007050 cell cycle arrest
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048416
View Gene Order
ENSBTAG00000004126
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.605551
RefSeq NM_001130156 NM_001130157 NM_001195432 NM_001195433 NM_001195434 NM_022443 XM_005247479 XM_005247480 XM_006713645
HUGO
OMIM
CCDS CCDS3182 CCDS46945 CCDS56286 CCDS56287 CCDS56288
HPRD 03239
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca