Homo sapiens Gene: INPPL1
Summary
InnateDB Gene IDBG-63291.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol INPPL1
Gene Name inositol polyphosphate phosphatase-like 1
Synonyms OPSMD; SHIP2;
Species Homo sapiens
Ensembl Gene ENSG00000165458
Encoded Proteins
inositol polyphosphate phosphatase-like 1
inositol polyphosphate phosphatase-like 1
inositol polyphosphate phosphatase-like 1
inositol polyphosphate phosphatase-like 1
inositol polyphosphate phosphatase-like 1
inositol polyphosphate phosphatase-like 1
inositol polyphosphate phosphatase-like 1
inositol polyphosphate phosphatase-like 1
inositol polyphosphate phosphatase-like 1
inositol polyphosphate phosphatase-like 1
inositol polyphosphate phosphatase-like 1
Protein Structure
Entrez Gene
Summary The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:71934745-71950149
Strand Forward strand
Band q13.4
Transcripts
ENST00000320683 ENSP00000321775
ENST00000298229 ENSP00000298229
ENST00000540973 ENSP00000440904
ENST00000545256 ENSP00000439160
ENST00000543234 ENSP00000440512
ENST00000541544
ENST00000538751 ENSP00000444619
ENST00000540329 ENSP00000440018
ENST00000537656 ENSP00000444630
ENST00000538339
ENST00000537755
ENST00000544806
ENST00000541303
ENST00000542295
ENST00000545355
ENST00000535985 ENSP00000437852
ENST00000541752 ENSP00000441094
ENST00000541756 ENSP00000446360
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 86 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0016787 hydrolase activity
GO:0017124 SH3 domain binding
GO:0042169 SH2 domain binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006644 phospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006897 endocytosis
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007420 brain development
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell proliferation
GO:0009791 post-embryonic development
GO:0010629 negative regulation of gene expression
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0010977 negative regulation of neuron projection development
GO:0032868 response to insulin stimulus
GO:0032957 inositol trisphosphate metabolic process
GO:0042493 response to drug
GO:0043407 negative regulation of MAP kinase activity
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046854 phosphatidylinositol phosphorylation
GO:0097178 ruffle assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030027 lamellipodium
GO:0030479 actin cortical patch
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
IL6 pathway
REACTOME
Interleukin receptor SHC signaling pathway
Synthesis of PIPs at the plasma membrane pathway
KEGG
Phosphatidylinositol signaling system pathway
Inositol phosphate metabolism pathway
Metabolic pathways pathway
INOH
Inositol phosphate metabolism pathway
PID BIOCARTA
Skeletal muscle hypertrophy is regulated via akt-mtor pathway [Biocarta view]
PID NCI
EPHA2 forward signaling
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Cross-References
SwissProt O15357
TrEMBL F5GY16 F5GYK9 F5H3D8 F5H588 H0YFZ4
UniProt Splice Variant
Entrez Gene 3636
UniGene Hs.523875 Hs.705937
RefSeq NM_001567
HUGO 6080
OMIM 600829
CCDS CCDS8213
HPRD 02900
IMGT
EMBL AP000593 BC140853 CH471076 L24444 L36818 Y14385
GenPept AAA50503 AAA96658 AAI40854 CAA74743 EAW74855
ImmGen INPPL1 (murine)
RNA Seq Atlas 3636