InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: S100A10

Summary

InnateDB Gene

IDBG-632987.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100A10

Gene Name

Protein S100-A10

Synonyms

p11

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015147

Encoded Proteins

IDBP-684648

Protein S100-A10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21115493

[Homo sapiens] S100A10 :: ANXA2 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce disassociation of the heterotetramer and ubiquitin-mediated degradation of S100A10.

PMID 21115493

[Mus musculus] S100a10 :: Anxa2 is a key profibrinolytic complex that assembles plasminogen and tissue plasminogen activator, and promotes plasmin generation. As a negative feedback regulation, plasmin can induce disassociation of the heterotetramer and ubiquitin-mediated degradation of S100a10.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197747:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:18799612-18810545

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020150

ENSBTAP00000020150

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0044325	ion channel binding

Biological Process

GO:0001765	membrane raft assembly
GO:0006900	membrane budding
GO:0032855	positive regulation of Rac GTPase activity
GO:0051099	positive regulation of binding
GO:0051290	protein heterotetramerization
GO:0051496	positive regulation of stress fiber assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:0071229	cellular response to acid
GO:0090002	establishment of protein localization to plasma membrane
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading