InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: P2RX1

Summary

InnateDB Gene

IDBG-633428.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RX1

Gene Name

P2X purinoceptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007169

Encoded Proteins

IDBP-685151

purinergic receptor P2X, ligand-gated ion channel, 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108405:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the P2X family of G-protein-coupled receptors. These proteins can form homo-and heterotimers and function as ATP-gated ion channels and mediate rapid and selective permeability to cations. This protein is primarily localized to smooth muscle where binds ATP and mediates synaptic transmission between neurons and from neurons to smooth muscle and may being responsible for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. This protein may also be involved in promoting apoptosis. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:25140459-25157998

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000009437

ENSBTAP00000009437

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005524	ATP binding

Biological Process

GO:0002554	serotonin secretion by platelet
GO:0003056	regulation of vascular smooth muscle contraction
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006940	regulation of smooth muscle contraction
GO:0007320	insemination
GO:0010033	response to organic substance
GO:0019229	regulation of vasoconstriction
GO:0030168	platelet activation
GO:0033198	response to ATP
GO:0034220	ion transmembrane transport
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0043270	positive regulation of ion transport
GO:0046513	ceramide biosynthetic process
GO:0051924	regulation of calcium ion transport

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031240	external side of cell outer membrane
GO:0045211	postsynaptic membrane