InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GLA

Summary

InnateDB Gene

IDBG-633622.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLA

Gene Name

alpha-galactosidase A

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000019256

Encoded Proteins

IDBP-685337

galactosidase, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102393:
This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:55224014-55234673

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000025636

ENSBTAP00000025636

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004557	alpha-galactosidase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0042803	protein homodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0008152	metabolic process
GO:0009311	oligosaccharide metabolic process
GO:0016139	glycoside catabolic process
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0046477	glycosylceramide catabolic process
GO:0051001	negative regulation of nitric-oxide synthase activity