InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MAPK8IP3

Summary

InnateDB Gene

IDBG-634758.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAPK8IP3

Gene Name

C-Jun-amino-terminal kinase-interacting protein 3

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002211

Encoded Proteins

IDBP-686580

mitogen-activated protein kinase 8 interacting protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138834:
The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 25:1304435-1348409

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002865

ENSBTAP00000002865

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005078	MAP-kinase scaffold activity
GO:0005515	protein binding
GO:0008432	JUN kinase binding
GO:0016301	kinase activity
GO:0019894	kinesin binding
GO:0019901	protein kinase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0007411	axon guidance
GO:0007585	respiratory gaseous exchange
GO:0008104	protein localization
GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0016192	vesicle-mediated transport
GO:0016310	phosphorylation
GO:0030900	forebrain development
GO:0043507	positive regulation of JUN kinase activity
GO:0046328	regulation of JNK cascade
GO:0048286	lung alveolus development
GO:0060425	lung morphogenesis

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005790	smooth endoplasmic reticulum
GO:0005886	plasma membrane
GO:0030425	dendrite
GO:0030673	axolemma

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000138834

View Gene Order

ENSMUSG00000024163

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

fak_pathway

Signaling events mediated by focal adhesion kinase

arf6_traffickingpathway

Arf6 trafficking events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.24378

RefSeq

NM_001076096 XM_005224532 XM_005224533 XM_005224538

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas