Version 5.4
Bos taurus Gene: WASL
Summary
InnateDB Gene IDBG-634828.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WASL
Gene Name Neural Wiskott-Aldrich syndrome protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004643
Encoded Proteins
IDBP-686633
Neural Wiskott-Aldrich syndrome protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106299:
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:88776840-88856547
Strand Reverse strand
Band
Transcripts
ENSBTAT00000006094 ENSBTAP00000006094
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007015 actin filament organization
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0009617 response to bacterium
GO:0030036 actin cytoskeleton organization
GO:0032880 regulation of protein localization
GO:0034629 cellular protein complex localization
GO:0051301 cell division
GO:0051653 spindle localization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0030027 lamellipodium
GO:0030478 actin cap
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000106299
View Gene Order
ENSMUSG00000029684
View Gene Order
Pathways
NETPATH
REACTOME
REACT_215545
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_226967
NOSTRIN mediated eNOS trafficking pathway
REACT_226352
eNOS activation and regulation pathway
REACT_216118
DCC mediated attractive signaling pathway
REACT_220341
Metabolism of nitric oxide pathway
REACT_205744
Netrin-1 signaling pathway
REACT_211504
Nephrin interactions pathway
REACT_213138
Immune System pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_206475
Cell-Cell communication pathway
REACT_211475
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_203140
Axon guidance pathway
REACT_219139
Metabolism pathway
REACT_259381
EPHB-mediated forward signaling pathway
REACT_216714
Innate Immune System pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_12541
NOSTRIN mediated eNOS trafficking pathway
REACT_23832
Nephrin interactions pathway
REACT_22351
DCC mediated attractive signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_12389
eNOS activation and regulation pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_6802
Innate Immune System pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_18266
Axon guidance pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_111217
Metabolism pathway
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_257032
Nephrin interactions pathway
REACT_204801
eNOS activation and regulation pathway
REACT_229826
Netrin-1 signaling pathway
REACT_215995
NOSTRIN mediated eNOS trafficking pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_248291
DCC mediated attractive signaling pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_261444
Axon guidance pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188576
Developmental Biology pathway
REACT_208364
Metabolism of nitric oxide pathway
REACT_223082
Cell-Cell communication pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04520
Adherens junction pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04520
Adherens junction pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
netrin_pathway
Netrin-mediated signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
ephbfwdpathway
EPHB forward signaling
cdc42_pathway
CDC42 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.359
RefSeq NM_174219
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca