Version 5.4
Homo sapiens Gene: SMC4
Summary
InnateDB Gene IDBG-63513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMC4
Gene Name structural maintenance of chromosomes 4
Synonyms CAP-C; CAPC; hCAP-C; SMC-4; SMC4L1
Species Homo sapiens
Ensembl Gene ENSG00000113810
Encoded Proteins
IDBP-63515
structural maintenance of chromosomes 4
IDBP-63519
structural maintenance of chromosomes 4
IDBP-474946
structural maintenance of chromosomes 4
IDBP-484880
structural maintenance of chromosomes 4
IDBP-474633
structural maintenance of chromosomes 4
IDBP-479014
structural maintenance of chromosomes 4
IDBP-473453
structural maintenance of chromosomes 4
IDBP-478128
structural maintenance of chromosomes 4
IDBP-474938
structural maintenance of chromosomes 4
IDBP-481327
structural maintenance of chromosomes 4
IDBP-477045
structural maintenance of chromosomes 4
IDBP-484363
structural maintenance of chromosomes 4
IDBP-476060
structural maintenance of chromosomes 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:160399274-160434962
Strand Forward strand
Band q25.33
Transcripts
ENST00000357388 ENSP00000349961
ENST00000344722 ENSP00000341382
ENST00000497311 ENSP00000418820
ENST00000465903 ENSP00000419247
ENST00000485645 ENSP00000420644
ENST00000472991 ENSP00000417999
ENST00000472282
ENST00000468653
ENST00000469762 ENSP00000417964
ENST00000467468 ENSP00000419360
ENST00000469858 ENSP00000418434
ENST00000489573 ENSP00000420121
ENST00000462787 ENSP00000420734
ENST00000490207 ENSP00000420817
ENST00000485867 ENSP00000417612
ENST00000470240
ENST00000497984
ENST00000487747
ENST00000465563
ENST00000494612
ENST00000467263
ENST00000462668
ENST00000493695
ENST00000484799
ENST00000497203
ENST00000488017
ENST00000486711
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated
Total 47 [view]
Protein-Protein 43 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000278 mitotic cell cycle
GO:0006935 chemotaxis
GO:0007076 mitotic chromosome condensation
GO:0007165 signal transduction
GO:0010032 meiotic chromosome condensation
GO:0045132 meiotic chromosome segregation
GO:0051276 chromosome organization
GO:0051383 kinetochore organization
Cellular Component
GO:0000796 condensin complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034349
View Gene Order
ENSBTAG00000005862
Not yet available
Pathways
NETPATH
REACTOME
REACT_150260
Condensation of Prometaphase Chromosomes pathway
REACT_682
Mitotic Prometaphase pathway
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
KEGG
INOH
PID NCI
aurora_b_pathway
Aurora B signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.58992
RefSeq NM_001002800 NM_001288753 NM_005496
HUGO
OMIM
CCDS CCDS3189 CCDS75046
HPRD 09276
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca