Bos taurus Gene: B4GALT1
Summary
InnateDB Gene IDBG-635744.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol B4GALT1
Gene Name Beta-1,4-galactosyltransferase 1 Lactose synthase A protein N-acetyllactosamine synthase Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase Processed beta-1,4-gala /.../transferase 1
Synonyms GGTB2
Species Bos taurus
Ensembl Gene ENSBTAG00000015249
Encoded Proteins
Beta-1,4-galactosyltransferase 1Lactose synthase A proteinN-acetyllactosamine synthaseBeta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferaseBeta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferaseProcessed beta-1,4-galactosyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000086062:
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene is unique among the beta4GalT genes because it encodes an enzyme that participates both in glycoconjugate and lactose biosynthesis. For the first activity, the enzyme adds galactose to N-acetylglucosamine residues that are either monosaccharides or the nonreducing ends of glycoprotein carbohydrate chains. The second activity is restricted to lactating mammary tissues where the enzyme forms a heterodimer with alpha-lactalbumin to catalyze UDP-galactose + D-glucose <=> UDP + lactose. The two enzymatic forms result from alternate transcription initiation sites and post-translational processing. Two transcripts, which differ only at the 5\' end, with approximate lengths of 4.1 kb and 3.9 kb encode the same protein. The longer transcript encodes the type II membrane-bound, trans-Golgi resident protein involved in glycoconjugate biosynthesis. The shorter transcript encodes a protein which is cleaved to form the soluble lactose synthase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:76176882-76232330
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020286 ENSBTAP00000020286
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0003945 N-acetyllactosamine synthase activity
GO:0004461 lactose synthase activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008378 galactosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0030145 manganese ion binding
GO:0035250 UDP-galactosyltransferase activity
GO:0042803 protein homodimerization activity
GO:0043014 alpha-tubulin binding
GO:0046872 metal ion binding
GO:0048487 beta-tubulin binding
Biological Process
GO:0002064 epithelial cell development
GO:0002526 acute inflammatory response
GO:0005975 carbohydrate metabolic process
GO:0005989 lactose biosynthetic process
GO:0006012 galactose metabolic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0007155 cell adhesion
GO:0007339 binding of sperm to zona pellucida
GO:0007341 penetration of zona pellucida
GO:0008285 negative regulation of cell proliferation
GO:0009101 glycoprotein biosynthetic process
GO:0009312 oligosaccharide biosynthetic process
GO:0030198 extracellular matrix organization
GO:0030879 mammary gland development
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0045136 development of secondary sexual characteristics
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050900 leukocyte migration
GO:0051270 regulation of cellular component movement
GO:0060046 regulation of acrosome reaction
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
GO:0060055 angiogenesis involved in wound healing
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
Cellular Component
GO:0000138 Golgi trans cisterna
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030057 desmosome
GO:0030112 glycocalyx
GO:0031526 brush border membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Defective EXT2 causes exostoses 2 pathway
Defective CHST6 causes MCDC1 pathway
MPS IIIA - Sanfilippo syndrome A pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
N-Glycan antennae elongation pathway
Signaling by NOTCH pathway
Glycosaminoglycan metabolism pathway
Defective CHSY1 causes TPBS pathway
MPS I - Hurler syndrome pathway
MPS IIID - Sanfilippo syndrome D pathway
Diseases associated with glycosaminoglycan metabolism pathway
Transport to the Golgi and subsequent modification pathway
Fertilization pathway
MPS IX - Natowicz syndrome pathway
Pre-NOTCH Expression and Processing pathway
Myoclonic epilepsy of Lafora pathway
MPS II - Hunter syndrome pathway
MPS VII - Sly syndrome pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Defective B3GAT3 causes JDSSDHD pathway
Asparagine N-linked glycosylation pathway
Mucopolysaccharidoses pathway
Signal Transduction pathway
Diseases of glycosylation pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Reproduction pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
MPS IIIC - Sanfilippo syndrome C pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
Defective CHST3 causes SEDCJD pathway
Metabolism pathway
Keratan sulfate biosynthesis pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Pre-NOTCH Processing in Golgi pathway
Defective SLC26A2 causes chondrodysplasias pathway
Interaction With The Zona Pellucida pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome A pathway
MPS IV - Morquio syndrome B pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Disease pathway
Keratan sulfate/keratin metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Pre-NOTCH Processing in Golgi pathway
N-Glycan antennae elongation pathway
Transport to the Golgi and subsequent modification pathway
Asparagine N-linked glycosylation pathway
Keratan sulfate biosynthesis pathway
Mucopolysaccharidoses pathway
Post-translational protein modification pathway
Pre-NOTCH Expression and Processing pathway
Interaction With The Zona Pellucida pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
Keratan sulfate/keratin metabolism pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
MPS IIID - Sanfilippo syndrome D pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Defective SLC26A2 causes chondrodysplasias pathway
Signal Transduction pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Fertilization pathway
Metabolism of proteins pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Reproduction pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
MPS II - Hunter syndrome pathway
Signaling by NOTCH pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
MPS VII - Sly syndrome pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
Glycosaminoglycan metabolism pathway
Keratan sulfate biosynthesis pathway
Disease pathway
N-Glycan antennae elongation pathway
N-glycan antennae elongation in the medial/trans-Golgi pathway
Transport to the Golgi and subsequent modification pathway
MPS IV - Morquio syndrome B pathway
MPS IV - Morquio syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
Metabolism of proteins pathway
MPS IIID - Sanfilippo syndrome D pathway
Post-translational protein modification pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Diseases of glycosylation pathway
Defective CHSY1 causes TPBS pathway
Defective B3GAT3 causes JDSSDHD pathway
MPS II - Hunter syndrome pathway
Diseases associated with glycosaminoglycan metabolism pathway
Pre-NOTCH Expression and Processing pathway
MPS IX - Natowicz syndrome pathway
Glycogen storage diseases pathway
MPS VII - Sly syndrome pathway
Defective CHST14 causes EDS, musculocontractural type pathway
Defective CHST3 causes SEDCJD pathway
Asparagine N-linked glycosylation pathway
Fertilization pathway
Reproduction pathway
Pre-NOTCH Processing in Golgi pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Interaction With The Zona Pellucida pathway
Keratan sulfate/keratin metabolism pathway
MPS IIIB - Sanfilippo syndrome B pathway
MPS IIIA - Sanfilippo syndrome A pathway
Signal Transduction pathway
Defective PAPSS2 causes SEMD-PA pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Signaling by NOTCH pathway
Mucopolysaccharidoses pathway
Defective CHST6 causes MCDC1 pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Defective EXT2 causes exostoses 2 pathway
Defective SLC26A2 causes chondrodysplasias pathway
KEGG
Galactose metabolism pathway
N-Glycan biosynthesis pathway
Glycosphingolipid biosynthesis pathway
Glycosaminoglycan biosynthesis pathway
Other types of O-glycan biosynthesis pathway
N-Glycan biosynthesis pathway
Galactose metabolism pathway
Glycosphingolipid biosynthesis pathway
Glycosaminoglycan biosynthesis pathway
Other types of O-glycan biosynthesis pathway
INOH
Galactose metabolism pathway
PID NCI
Cross-References
SwissProt P08037
TrEMBL
UniProt Splice Variant
Entrez Gene 281781
UniGene Bt.5141 Bt.75970
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF515786 BC120415 J05217 M13214 M25398 X14558
GenPept AAA30533 AAA30534 AAA30559 AAI20416 AAM54035 CAA32695
RNA Seq Atlas 281781