Version 5.4
Homo sapiens Gene: TCTN2
Summary
InnateDB Gene IDBG-63665.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCTN2
Gene Name tectonic family member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168778
Encoded Proteins
IDBP-63669
tectonic family member 2
IDBP-384890
tectonic family member 2
IDBP-585292
tectonic family member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type I membrane protein that belongs to the tectonic family. Studies in mice suggest that this protein may be involved in hedgehog signaling, and essential for ciliogenesis. Mutations in this gene are associated with Meckel syndrome type 8. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:123671113-123708403
Strand Forward strand
Band q24.31
Transcripts
ENST00000303372 ENSP00000304941
ENST00000426174 ENSP00000395171
ENST00000541523 ENSP00000437644
ENST00000543998
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007224 smoothened signaling pathway
GO:0042384 cilium assembly
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0016021 integral component of membrane
GO:0036038 TCTN-B9D complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029386
View Gene Order
ENSBTAG00000007271
Not yet available
Cross-References
SwissProt Q96GX1
TrEMBL F5H6G0
UniProt Splice Variant
Entrez Gene 79867
UniGene Hs.167165
RefSeq NM_001143850 NM_024809 XM_006719605
HUGO HGNC:25774
OMIM 613846
CCDS CCDS45007 CCDS9253
HPRD
IMGT
EMBL AC117503 AK023037 AK056924 AK292153 BC009112 CH471054 DQ278870
GenPept AAH09112 ABB90562 BAB14370 BAF84842 BAG51827 EAW98430
RNA Seq Atlas 79867

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca