InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BCL2L1

Summary

InnateDB Gene

IDBG-63673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCL2L1

Gene Name

BCL2-like 1

Synonyms

Bcl-X; bcl-xL; BCL-XL/S; bcl-xS; BCL2L; BCLX; BCLXL; BCLXS; PPP1R52

Species

Homo sapiens

Ensembl Gene

ENSG00000171552

Encoded Proteins

IDBP-63675

BCL2-like 1

IDBP-63677

BCL2-like 1

IDBP-63681

BCL2-like 1

IDBP-370467

BCL2-like 1

IDBP-370475

BCL2-like 1

IDBP-370479

BCL2-like 1

IDBP-370484

BCL2-like 1

IDBP-370485

BCL2-like 1

IDBP-370487

BCL2-like 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24412611

[Mus musculus] Microbiota-driven Il17c induces Bcl2 and Bcl2l1 expression in intestinal epithelial cells in an autocrine manner to promote cell survival and tumorigenesis in both chemically induced and spontaneous intestinal tumor models.

Entrez Gene

Summary

The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:31664452-31723989

Strand

Reverse strand

Band

q11.21

Transcripts

ENST00000307677	ENSP00000302564
ENST00000376062	ENSP00000365230
ENST00000376055	ENSP00000365223
ENST00000450273	ENSP00000406203
ENST00000420488	ENSP00000390760
ENST00000456404	ENSP00000395545
ENST00000422920	ENSP00000411252
ENST00000439267	ENSP00000389688
ENST00000434194	ENSP00000401173

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 177 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	177 [view]
Protein-Protein	173 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051434	BH3 domain binding

Biological Process

GO:0000910	cytokinesis
GO:0001541	ovarian follicle development
GO:0001701	in utero embryonic development
GO:0001836	release of cytochrome c from mitochondria
GO:0006897	endocytosis
GO:0006915	apoptotic process
GO:0007093	mitotic cell cycle checkpoint
GO:0007281	germ cell development
GO:0007283	spermatogenesis
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008584	male gonad development
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637	apoptotic mitochondrial changes
GO:0009314	response to radiation
GO:0009566	fertilization
GO:0009615	response to virus
GO:0010507	negative regulation of autophagy
GO:0019050	suppression by virus of host apoptotic process
GO:0034097	response to cytokine
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0040007	growth
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045087	innate immune response
GO:0046898	response to cycloheximide
GO:0046902	regulation of mitochondrial membrane permeability
GO:0051402	neuron apoptotic process
GO:0051881	regulation of mitochondrial membrane potential
GO:0060154	cellular process regulating host cell cycle in response to virus
GO:0070584	mitochondrion morphogenesis
GO:0071230	cellular response to amino acid stimulus
GO:0071312	cellular response to alkaloid
GO:0071480	cellular response to gamma radiation
GO:0071839	apoptotic process in bone marrow
GO:0090005	negative regulation of establishment of protein localization to plasma membrane
GO:0090201	negative regulation of release of cytochrome c from mitochondria
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097284	hepatocyte apoptotic process
GO:1900118	negative regulation of execution phase of apoptosis
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000811	negative regulation of anoikis
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031965	nuclear membrane
GO:0031966	mitochondrial membrane
GO:0097136	Bcl-2 family protein complex