Bos taurus Gene: IL2RA | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-637067.2 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | IL2RA | ||||||||||||||||
Gene Name | interleukin-2 receptor subunit alpha precursor | ||||||||||||||||
Synonyms | CD25 | ||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000020892 | ||||||||||||||||
Encoded Proteins |
interleukin-2 receptor subunit alpha precursor
interleukin-2 receptor subunit alpha precursor
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134460:
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 13:17540961-17586321 | ||||||||||||||||
Strand | Forward strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
IL2 pathway
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REACTOME |
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
GPVI-mediated activation cascade pathway
G beta:gamma signalling through PI3Kgamma pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
Signaling by Interleukins pathway
Hemostasis pathway
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Interleukin-2 signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
GPVI-mediated activation cascade pathway
Interleukin receptor SHC signaling pathway
Signaling by Interleukins pathway
G-protein beta:gamma signalling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Signal Transduction pathway
G beta:gamma signalling through PI3Kgamma pathway
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KEGG |
Hematopoietic cell lineage pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Endocytosis pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
Endocytosis pathway
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INOH |
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
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PID NCI |
Calcium signaling in the CD4+ TCR pathway
IL2-mediated signaling events
Downstream signaling in naïve CD8+ T cells
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
IL12 signaling mediated by STAT4
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | A2VE30 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 281861 | ||||||||||||||||
UniGene | Bt.3941 | ||||||||||||||||
RefSeq | NM_174358 XM_005214133 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | BC133546 DAAA02035345 | ||||||||||||||||
GenPept | AAI33547 | ||||||||||||||||
RNA Seq Atlas | 281861 | ||||||||||||||||