Bos taurus Gene: F2 | |||||||||||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-637247.3 | ||||||||||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||
Gene Symbol | F2 | ||||||||||||||||||||||||||||||||||||||||||||||
Gene Name | Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain | ||||||||||||||||||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000007148 | ||||||||||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
ProthrombinActivation peptide fragment 1Activation peptide fragment 2Thrombin light chainThrombin heavy chain
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Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180210:
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008] Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 15:77530565-77544935 | ||||||||||||||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||
REACTOME |
Gamma-carboxylation of protein precursors pathway
Cell surface interactions at the vascular wall pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Common Pathway pathway
Signaling by GPCR pathway
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
Intrinsic Pathway pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Platelet Aggregation (Plug Formation) pathway
Signal Transduction pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
G alpha (q) signalling events pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Class A/1 (Rhodopsin-like receptors) pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
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KEGG | |||||||||||||||||||||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||
REACTOME |
Cell surface interactions at the vascular wall pathway
Intrinsic Pathway pathway
Common Pathway pathway
Platelet Aggregation (Plug Formation) pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
Gamma-carboxylation of protein precursors pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Post-translational protein modification pathway
Signaling by GPCR pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Metabolism of proteins pathway
GPCR ligand binding pathway
Hemostasis pathway
GPCR downstream signaling pathway
Hemostasis pathway
Signaling by GPCR pathway
Class A/1 (Rhodopsin-like receptors) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus pathway
Cell surface interactions at the vascular wall pathway
Platelet activation, signaling and aggregation pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway
Intrinsic Pathway pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins pathway
Gamma-carboxylation of protein precursors pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
GPCR ligand binding pathway
Peptide ligand-binding receptors pathway
Removal of aminoterminal propeptides from gamma-carboxylated proteins pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
G alpha (q) signalling events pathway
Common Pathway pathway
Signal Transduction pathway
Platelet Aggregation (Plug Formation) pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Neuroactive ligand-receptor interaction pathway
Complement and coagulation cascades pathway
Neuroactive ligand-receptor interaction pathway
Regulation of actin cytoskeleton pathway
Complement and coagulation cascades pathway
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INOH | |||||||||||||||||||||||||||||||||||||||||||||||
PID NCI |
FOXA2 and FOXA3 transcription factor networks
PAR1-mediated thrombin signaling events
Angiopoietin receptor Tie2-mediated signaling
Thrombin/protease-activated receptor (PAR) pathway
Syndecan-4-mediated signaling events
PAR4-mediated thrombin signaling events
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Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||
SwissProt | P00735 | ||||||||||||||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||
Entrez Gene | 280685 | ||||||||||||||||||||||||||||||||||||||||||||||
UniGene | Bt.29855 | ||||||||||||||||||||||||||||||||||||||||||||||
RefSeq | NM_173877 XM_005216401 | ||||||||||||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||||||||||
EMBL | BC105201 J00041 V00135 | ||||||||||||||||||||||||||||||||||||||||||||||
GenPept | AAA30781 AAI05202 CAA23451 | ||||||||||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 280685 | ||||||||||||||||||||||||||||||||||||||||||||||