InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HSD17B10

Summary

InnateDB Gene

IDBG-637418.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSD17B10

Gene Name

3-hydroxyacyl-CoA dehydrogenase type-2

Synonyms

HADH2

Species

Bos taurus

Ensembl Gene

ENSBTAG00000017779

Encoded Proteins

IDBP-689422

3-hydroxyacyl-CoA dehydrogenase type-2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000072506:
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:96267144-96269467

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000023642

ENSBTAP00000023642

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0030283	testosterone dehydrogenase [NAD(P)] activity
GO:0044822	poly(A) RNA binding
GO:0047015	3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity