Version 5.4
Homo sapiens Gene: SI
Summary
InnateDB Gene IDBG-63763.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SI
Gene Name sucrase-isomaltase (alpha-glucosidase)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000090402
Encoded Proteins
IDBP-63765
sucrase-isomaltase (alpha-glucosidase)
IDBP-478129
sucrase-isomaltase (alpha-glucosidase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:164978898-165078495
Strand Reverse strand
Band q26.1
Transcripts
ENST00000264382 ENSP00000264382
ENST00000476593 ENSP00000419450
ENST00000463607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004558 alpha-glucosidase activity
GO:0004574 oligo-1,6-glucosidase activity
GO:0004575 sucrose alpha-glucosidase activity
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0044245 polysaccharide digestion
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027790
View Gene Order
ENSBTAG00000006975
Not yet available
Pathways
NETPATH
REACTOME
REACT_9472
Digestion of dietary carbohydrate pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00500
Starch and sucrose metabolism pathway
hsa04973
Carbohydrate digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt P14410
TrEMBL F8WF21
UniProt Splice Variant
Entrez Gene 6476
UniGene Hs.429596 Hs.627342
RefSeq NM_001041
HUGO HGNC:10856
OMIM 609845
CCDS CCDS3196
HPRD
IMGT
EMBL AC092695 AC140119 AC144561 BC115034 BC116452 BC132834 BC132860 M22616 X63597
GenPept AAA60551 AAI15035 AAI16453 AAI32835 AAI32861 CAA45140
RNA Seq Atlas 6476

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca