Version 5.4
Bos taurus Gene: PHEX
Summary
InnateDB Gene IDBG-638467.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PHEX
Gene Name phosphate-regulating neutral endopeptidase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000419
Encoded Proteins
IDBP-690539
phosphate regulating endopeptidase homolog, X-linked
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102174:
The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:128333460-128534906
Strand Reverse strand
Band
Transcripts
ENSBTAT00000000540 ENSBTAP00000000540
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019637 organophosphate metabolic process
GO:0030282 bone mineralization
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000102174
View Gene Order
ENSMUSG00000057457
View Gene Order
Cross-References
SwissProt
TrEMBL E1BKS5
UniProt Splice Variant
Entrez Gene 536029
UniGene Bt.62478
RefSeq NM_001192871
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02074497 DAAA02074498 DAAA02074499 DAAA02074500 DAAA02074501 DAAA02074502 DAAA02074503
GenPept
RNA Seq Atlas 536029

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca