Version 5.4
Homo sapiens Gene: NCOR2
Summary
InnateDB Gene IDBG-63911.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCOR2
Gene Name nuclear receptor corepressor 2
Synonyms CTG26; N-CoR2; SMAP270; SMRT; SMRTE; SMRTE-tau; TNRC14; TRAC; TRAC-1; TRAC1
Species Homo sapiens
Ensembl Gene ENSG00000196498
Encoded Proteins
IDBP-63913
nuclear receptor corepressor 2
IDBP-293637
nuclear receptor corepressor 2
IDBP-293629
nuclear receptor corepressor 2
IDBP-293635
nuclear receptor corepressor 2
IDBP-384986
nuclear receptor corepressor 2
IDBP-384991
nuclear receptor corepressor 2
IDBP-384994
nuclear receptor corepressor 2
IDBP-384996
nuclear receptor corepressor 2
IDBP-384997
nuclear receptor corepressor 2
IDBP-384999
nuclear receptor corepressor 2
IDBP-385000
nuclear receptor corepressor 2
IDBP-385001
nuclear receptor corepressor 2
IDBP-385003
nuclear receptor corepressor 2
IDBP-385004
nuclear receptor corepressor 2
IDBP-583216
nuclear receptor corepressor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:124324415-124567589
Strand Reverse strand
Band q24.31
Transcripts
ENST00000356219 ENSP00000348551
ENST00000404121 ENSP00000385618
ENST00000404621 ENSP00000384202
ENST00000405201 ENSP00000384018
ENST00000429285 ENSP00000400281
ENST00000443451
ENST00000418829 ENSP00000391389
ENST00000413172 ENSP00000407357
ENST00000440337 ENSP00000398963
ENST00000440187 ENSP00000396044
ENST00000453428 ENSP00000400687
ENST00000458234 ENSP00000402808
ENST00000448614 ENSP00000408247
ENST00000420698 ENSP00000405367
ENST00000448008 ENSP00000403034
ENST00000464377
ENST00000461081
ENST00000474079
ENST00000473999
ENST00000493859
ENST00000494460
ENST00000536195
ENST00000542927 ENSP00000443689
ENST00000542565
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 188 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 188 [view]
Protein-Protein 173 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 4 [view]
RNA-RNA 1 [view]
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001012 RNA polymerase II regulatory region DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0005112 Notch binding
GO:0005515 protein binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0032403 protein complex binding
GO:0035259 glucocorticoid receptor binding
GO:0042826 histone deacetylase binding
GO:0042974 retinoic acid receptor binding
GO:0043565 sequence-specific DNA binding
GO:0046965 retinoid X receptor binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0003007 heart morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007595 lactation
GO:0010243 response to organonitrogen compound
GO:0010467 gene expression
GO:0021537 telencephalon development
GO:0021846 cell proliferation in forebrain
GO:0030900 forebrain development
GO:0032355 response to estradiol
GO:0042593 glucose homeostasis
GO:0042698 ovulation cycle
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0050872 white fat cell differentiation
GO:0060206 estrous cycle phase
GO:0060509 Type I pneumocyte differentiation
GO:0072365 regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0016604 nuclear body
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029478
View Gene Order
ENSBTAG00000024603
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_3
Notch pathway
REACTOME
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_111045
Developmental Biology pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_228222
HDACs deacetylate histones pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_172623
Chromatin organization pathway
REACT_299
Signaling by NOTCH pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_111217
Metabolism pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04330
Notch signaling pathway pathway
INOH
PID NCI
rxr_vdr_pathway
RXR and RAR heterodimerization with other nuclear receptor
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
hdac_classi_pathway
Signaling events mediated by HDAC Class I
hdac_classii_pathway
Signaling events mediated by HDAC Class II
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9612
UniGene Hs.137510 Hs.672265 Hs.694316 Hs.736384 Hs.738464
RefSeq NM_001077261 NM_001206654 NM_006312
HUGO HGNC:7673
OMIM 600848
CCDS CCDS41857 CCDS41858 CCDS55892
HPRD 02910
IMGT
EMBL
GenPept
RNA Seq Atlas 9612

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca