InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CBLC

Summary

InnateDB Gene

IDBG-639272.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBLC

Gene Name

signal transduction protein CBL-C

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009494

Encoded Proteins

IDBP-691417

signal transduction protein CBL-C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142273:
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:52943365-52959011

Strand

Forward strand

Band

Transcripts

ENSBTAT00000043713

ENSBTAP00000041264

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005154	epidermal growth factor receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding
GO:0046872	metal ion binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0023051	regulation of signaling
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043407	negative regulation of MAP kinase activity