InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HDAC6

Summary

InnateDB Gene

IDBG-63929.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC6

Gene Name

histone deacetylase 6

Synonyms

CPBHM; HD6; PPP1R90

Species

Homo sapiens

Ensembl Gene

ENSG00000094631

Encoded Proteins

IDBP-63931

histone deacetylase 6

IDBP-63933

histone deacetylase 6

IDBP-63935

histone deacetylase 6

IDBP-63939

histone deacetylase 6

IDBP-370717

histone deacetylase 6

IDBP-370721

histone deacetylase 6

IDBP-370769

histone deacetylase 6

IDBP-370773

histone deacetylase 6

IDBP-370777

histone deacetylase 6

IDBP-370778

histone deacetylase 6

IDBP-370780

histone deacetylase 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:48801377-48824982

Strand

Forward strand

Band

p11.23

Transcripts

ENST00000376643	ENSP00000365831
ENST00000376619	ENSP00000365804
ENST00000334136	ENSP00000334061
ENST00000376610	ENSP00000365795
ENST00000423941	ENSP00000392815
ENST00000438518	ENSP00000403370
ENST00000441703	ENSP00000393916
ENST00000426196	ENSP00000402189
ENST00000443563	ENSP00000402751
ENST00000440653	ENSP00000394377
ENST00000430858	ENSP00000397697
ENST00000469223
ENST00000483656
ENST00000462730
ENST00000477528
ENST00000465269
ENST00000476625
ENST00000477561
ENST00000481929
ENST00000489352
ENST00000468949
ENST00000493923
ENST00000461608
ENST00000486227
ENST00000478095
ENST00000485102
ENST00000488905
ENST00000465457
ENST00000495515
ENST00000486665
ENST00000470942
ENST00000483506
ENST00000498808
ENST00000489053
ENST00000480525
ENST00000488543

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 303 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	303 [view]
Protein-Protein	250 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	47 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004407	histone deacetylase activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008017	microtubule binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0019899	enzyme binding
GO:0031593	polyubiquitin binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0042826	histone deacetylase binding
GO:0042903	tubulin deacetylase activity
GO:0043014	alpha-tubulin binding
GO:0043130	ubiquitin binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048156	tau protein binding
GO:0048487	beta-tubulin binding
GO:0051879	Hsp90 protein binding
GO:0070840	dynein complex binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000209	protein polyubiquitination
GO:0006351	transcription, DNA-templated
GO:0006476	protein deacetylation
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0006886	intracellular protein transport
GO:0007026	negative regulation of microtubule depolymerization
GO:0008152	metabolic process
GO:0009636	response to toxic substance
GO:0009967	positive regulation of signal transduction
GO:0010033	response to organic substance
GO:0010469	regulation of receptor activity
GO:0010634	positive regulation of epithelial cell migration
GO:0010727	negative regulation of hydrogen peroxide metabolic process
GO:0010870	positive regulation of receptor biosynthetic process
GO:0016236	macroautophagy
GO:0016575	histone deacetylation
GO:0032418	lysosome localization
GO:0034983	peptidyl-lysine deacetylation
GO:0035967	cellular response to topologically incorrect protein
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043241	protein complex disassembly
GO:0043242	negative regulation of protein complex disassembly
GO:0045861	negative regulation of proteolysis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0051354	negative regulation of oxidoreductase activity
GO:0051788	response to misfolded protein
GO:0060632	regulation of microtubule-based movement
GO:0060765	regulation of androgen receptor signaling pathway
GO:0070201	regulation of establishment of protein localization
GO:0070301	cellular response to hydrogen peroxide
GO:0070842	aggresome assembly
GO:0070845	polyubiquitinated misfolded protein transport
GO:0070846	Hsp90 deacetylation
GO:0070848	response to growth factor
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0071218	cellular response to misfolded protein
GO:0090035	positive regulation of chaperone-mediated protein complex assembly
GO:0090042	tubulin deacetylation
GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005875	microtubule associated complex
GO:0005881	cytoplasmic microtubule
GO:0005901	caveola
GO:0016234	inclusion body
GO:0016235	aggresome
GO:0030286	dynein complex
GO:0030424	axon
GO:0030425	dendrite
GO:0031252	cell leading edge
GO:0043204	perikaryon
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm