Version 5.4
Bos taurus Gene: ORC1
Summary
InnateDB Gene IDBG-639359.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORC1
Gene Name Origin recognition complex subunit 1
Synonyms ORC1L
Species Bos taurus
Ensembl Gene ENSBTAG00000002719
Encoded Proteins
IDBP-691516
origin recognition complex subunit 1
IDBP-691517
origin recognition complex subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000085840:
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:94543867-94575375
Strand Forward strand
Band
Transcripts
ENSBTAT00000052505 ENSBTAP00000048350
ENSBTAT00000003523 ENSBTAP00000003523
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006260 DNA replication
GO:0008152 metabolic process
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005664 nuclear origin of replication recognition complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000085840
View Gene Order
ENSMUSG00000028587
View Gene Order
Pathways
NETPATH
REACTOME
REACT_222889
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_225014
S Phase pathway
REACT_206368
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_224358
Mitotic G1-G1/S phases pathway
REACT_207739
DNA Replication Pre-Initiation pathway
REACT_213604
DNA Replication pathway
REACT_215677
Assembly of the pre-replicative complex pathway
REACT_204686
Association of licensing factors with the pre-replicative complex pathway
REACT_211609
G1/S Transition pathway
REACT_212671
Regulation of DNA replication pathway
REACT_213030
Orc1 removal from chromatin pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_201998
E2F mediated regulation of DNA replication pathway
REACT_224922
Synthesis of DNA pathway
REACT_214934
Cell Cycle pathway
REACT_208424
Assembly of the ORC complex at the origin of replication pathway
REACT_223713
CDC6 association with the ORC:origin complex pathway
REACT_226955
M/G1 Transition pathway
REACT_206537
G2/M Checkpoints pathway
REACT_221628
Activation of the pre-replicative complex pathway
REACT_227740
Activation of ATR in response to replication stress pathway
REACT_225533
G1/S-Specific Transcription pathway
REACT_205537
Removal of licensing factors from origins pathway
REACT_224819
Cell Cycle Checkpoints pathway
REACT_222483
Switching of origins to a post-replicative state pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6769
Activation of ATR in response to replication stress pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_1181
Association of licensing factors with the pre-replicative complex pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_1095
Activation of the pre-replicative complex pathway
REACT_1707
CDC6 association with the ORC:origin complex pathway
REACT_1949
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_567
Assembly of the ORC complex at the origin of replication pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_683
G1/S-Specific Transcription pathway
REACT_1321
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_383
DNA Replication pathway
REACT_2014
Synthesis of DNA pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_828
G2/M Checkpoints pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_829
Regulation of DNA replication pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_247969
Assembly of the ORC complex at the origin of replication pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_258062
Synthesis of DNA pathway
REACT_244558
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_232628
DNA Replication pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_188804
Cell Cycle pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_259974
CDC6 association with the ORC:origin complex pathway
REACT_255479
Regulation of DNA replication pathway
REACT_254983
Activation of the pre-replicative complex pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_245528
M/G1 Transition pathway
REACT_235397
G2/M Checkpoints pathway
REACT_204269
E2F-enabled inhibition of pre-replication complex formation pathway
REACT_262002
Association of licensing factors with the pre-replicative complex pathway
REACT_253002
G1/S Transition pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_198608
G1/S-Specific Transcription pathway
REACT_232236
Activation of ATR in response to replication stress pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_230841
Assembly of the pre-replicative complex pathway
REACT_253623
S Phase pathway
KEGG
hsa04110
Cell cycle pathway
mmu04110
Cell cycle pathway
INOH
PID NCI
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt Q58DC8
TrEMBL
UniProt Splice Variant
Entrez Gene 513523
UniGene Bt.2111
RefSeq NM_001014918 XM_005204545 XM_005204546 XM_005204547
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC133326 BT021669
GenPept AAI33327 AAX46516
RNA Seq Atlas 513523

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca