Version 5.4
Bos taurus Gene: ENDOG
Summary
InnateDB Gene IDBG-639600.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENDOG
Gene Name Endonuclease G, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012484
Encoded Proteins
IDBP-691774
Endonuclease G, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167136:
The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:99314600-99318324
Strand Forward strand
Band
Transcripts
ENSBTAT00000016564 ENSBTAP00000016564
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006309 apoptotic DNA fragmentation
GO:0034612 response to tumor necrosis factor
GO:0043065 positive regulation of apoptotic process
GO:0046677 response to antibiotic
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000167136
View Gene Order
ENSMUSG00000015337
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04210
Apoptosis pathway
mmu04210
Apoptosis pathway
INOH
PID NCI
Cross-References
SwissProt P38447
TrEMBL
UniProt Splice Variant
Entrez Gene 327707
UniGene Bt.103334
RefSeq NM_175823
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134634 X72802
GenPept AAI34635 CAA51320
RNA Seq Atlas 327707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca