InnateDB: Systems Biology of the Innate Immune Response

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:49976467-50025946

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000316763	ENSP00000324636
ENST00000377011	ENSP00000366210
ENST00000424804
ENST00000594090	ENSP00000469325
ENST00000601341	ENSP00000470156
ENST00000597215	ENSP00000470940
ENST00000593912	ENSP00000473222
ENST00000599342	ENSP00000471661
ENST00000600031
ENST00000600259	ENSP00000469400
ENST00000594948	ENSP00000473171
ENST00000593919	ENSP00000469710
ENST00000601849
ENST00000601324	ENSP00000470359
ENST00000596445	ENSP00000469092
ENST00000596814	ENSP00000472217
ENST00000596121	ENSP00000469802
ENST00000599138
ENST00000601912	ENSP00000471061
ENST00000598553
ENST00000600284
ENST00000594092	ENSP00000472541
ENST00000600137	ENSP00000468979
ENST00000599538	ENSP00000469880
ENST00000594104
ENST00000602029

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0070373	negative regulation of ERK1 and ERK2 cascade

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002205

View Gene Order

ENSBTAG00000005367

Not yet available

Cross-References

SwissProt

Q8IV63

TrEMBL

M0QXD7 M0QYA8 M0QZ79 M0R025

UniProt Splice Variant

Entrez Gene

51231

UniGene

RefSeq

XM_005258974 NM_001025778 NM_016440 XM_005258971 XM_005258972 XM_006723237 XM_006723238

HUGO

HGNC:18996

OMIM

CCDS

CCDS12791 CCDS33076

HPRD

18289

IMGT

EMBL

AB031052 AC011452 AF514788 AK292918 AK303010 BC023556 BC095449

GenPept

AAH23556 AAH95449 AAP47180 BAA90769 BAF85607 BAG64141

RNA Seq Atlas

51231