InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDCD10

Summary

InnateDB Gene

IDBG-64018.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD10

Gene Name

programmed cell death 10

Synonyms

CCM3; TFAR15

Species

Homo sapiens

Ensembl Gene

ENSG00000114209

Encoded Proteins

IDBP-245028

programmed cell death 10

IDBP-483532

programmed cell death 10

IDBP-481246

programmed cell death 10

IDBP-479376

programmed cell death 10

IDBP-478970

programmed cell death 10

IDBP-482093

programmed cell death 10

IDBP-480427

programmed cell death 10

IDBP-476882

programmed cell death 10

IDBP-477799

programmed cell death 10

IDBP-476469

programmed cell death 10

IDBP-483887

programmed cell death 10

IDBP-475870

programmed cell death 10

IDBP-484961

programmed cell death 10

IDBP-474364

programmed cell death 10

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:167683298-167734939

Strand

Reverse strand

Band

q26.1

Transcripts

ENST00000392750	ENSP00000376506
ENST00000473645	ENSP00000418317
ENST00000497056	ENSP00000420553
ENST00000492396	ENSP00000417309
ENST00000461494	ENSP00000420021
ENST00000470131	ENSP00000417202
ENST00000475915	ENSP00000417118
ENST00000487947	ENSP00000420266
ENST00000471885	ENSP00000417876
ENST00000479121	ENSP00000420308
ENST00000462725	ENSP00000420424
ENST00000492139	ENSP00000420014
ENST00000483451
ENST00000494502	ENSP00000420450
ENST00000462830
ENST00000464360	ENSP00000418160
ENST00000481136
ENST00000487678

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.

Experimentally validated
Total	70 [view]
Protein-Protein	65 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0047485	protein N-terminus binding

Biological Process

GO:0001525	angiogenesis
GO:0006915	apoptotic process
GO:0008284	positive regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043406	positive regulation of MAP kinase activity

Cellular Component

GO:0000139	Golgi membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027835

View Gene Order

ENSBTAG00000031709

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

myc_activpathway

Validated targets of C-MYC transcriptional activation

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.478150

RefSeq

NM_007217 NM_145859 NM_145860 XM_005247086 XM_005247087 XM_005247088 XM_006713485

HUGO

OMIM

CCDS

CCDS3202

HPRD

10141

IMGT

EMBL

GenPept

RNA Seq Atlas