Version 5.4
Homo sapiens Gene: UCP3
Summary
InnateDB Gene IDBG-64083.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCP3
Gene Name uncoupling protein 3 (mitochondrial, proton carrier)
Synonyms SLC25A9
Species Homo sapiens
Ensembl Gene ENSG00000175564
Encoded Proteins
IDBP-64085
uncoupling protein 3 (mitochondrial, proton carrier)
IDBP-380855
uncoupling protein 3 (mitochondrial, proton carrier)
IDBP-600931
uncoupling protein 3 (mitochondrial, proton carrier)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene\'s protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:74000281-74009435
Strand Reverse strand
Band q13.4
Transcripts
ENST00000314032 ENSP00000323740
ENST00000426995 ENSP00000392143
ENST00000545271
ENST00000544614 ENSP00000445279
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0017077 oxidative phosphorylation uncoupler activity
Biological Process
GO:0000303 response to superoxide
GO:0001666 response to hypoxia
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006839 mitochondrial transport
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007585 respiratory gaseous exchange
GO:0009409 response to cold
GO:0014823 response to activity
GO:0015992 proton transport
GO:0022904 respiratory electron transport chain
GO:0032868 response to insulin
GO:0032870 cellular response to hormone stimulus
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0048545 response to steroid hormone
GO:0051384 response to glucocorticoid
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032942
View Gene Order
ENSBTAG00000005259
Not yet available
Pathways
NETPATH
REACTOME
REACT_6258
The fatty acid cycling model pathway
REACT_6196
The proton buffering model pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_6341
Mitochondrial Uncoupling Proteins pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.101337
RefSeq NM_003356 NM_022803
HUGO
OMIM
CCDS CCDS44677 CCDS8229
HPRD 03623
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca