InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYH14

Summary

InnateDB Gene

IDBG-64099.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH14

Gene Name

myosin, heavy chain 14, non-muscle

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000105357

Encoded Proteins

IDBP-64101

myosin, heavy chain 14, non-muscle

IDBP-64103

myosin, heavy chain 14, non-muscle

IDBP-383740

myosin, heavy chain 14, non-muscle

IDBP-383741

myosin, heavy chain 14, non-muscle

IDBP-765831

IDBP-765963

IDBP-765610

IDBP-759838

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:50188186-50310545

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000376970	ENSP00000366169
ENST00000262269	ENSP00000262269
ENST00000440075	ENSP00000406273
ENST00000425460	ENSP00000407879
ENST00000596571	ENSP00000472819
ENST00000597072
ENST00000599920	ENSP00000469573
ENST00000601313	ENSP00000470298
ENST00000595016
ENST00000598205	ENSP00000472543

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0030898	actin-dependent ATPase activity
GO:0051015	actin filament binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0006200	ATP catabolic process
GO:0007411	axon guidance
GO:0007519	skeletal muscle tissue development
GO:0007605	sensory perception of sound
GO:0008152	metabolic process
GO:0008360	regulation of cell shape
GO:0014732	skeletal muscle atrophy
GO:0019228	neuronal action potential
GO:0030048	actin filament-based movement
GO:0031032	actomyosin structure organization
GO:0070584	mitochondrion morphogenesis
GO:0071625	vocalization behavior

Cellular Component

GO:0001725	stress fiber
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016459	myosin complex
GO:0016460	myosin II complex
GO:0030424	axon
GO:0030426	growth cone
GO:0042641	actomyosin
GO:0070062	extracellular vesicular exosome
GO:0097513	myosin II filament

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030739

View Gene Order

ENSBTAG00000002580

Not yet available

Pathways

NETPATH

REACTOME

REACT_19277

Sema4D induced cell migration and growth-cone collapse pathway

REACT_19259

Sema4D in semaphorin signaling pathway

REACT_111045

Developmental Biology pathway

REACT_19271

Semaphorin interactions pathway

REACT_18266

Axon guidance pathway

REACT_228063

EPHA-mediated growth cone collapse pathway

REACT_228170

EPH-Ephrin signaling pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04530

Tight junction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

M0QY43

UniProt Splice Variant

Entrez Gene

79784

UniGene

Hs.467142

RefSeq

NM_001077186 NM_001145809 NM_024729 XM_006723386

HUGO

HGNC:23212

OMIM

608568

CCDS

CCDS46151 CCDS54295 CCDS59411

HPRD

10543

IMGT

EMBL

AC008655 AC010515 AC020906

GenPept

RNA Seq Atlas

79784